LIF protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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experimentally determined

co-expression

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gene neighborhood

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gene fusions

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[Homology]

Score

LIF

LIF interleukin 6 family cytokine. (202 aa)

Predicted Functional Partners:

LIFR

0.996

CTF1

0.988

OSM

0.987

JAK1

0.973

JAK2

0.973

IL11

0.971

IL6

0.967

IL6ST

0.964

OSMR

0.923

LOC489915

0.920

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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structured XML interaction data, according to the 'PSI-MI' data standard

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTF1	IL11	ENSCAFP00000024588	ENSCAFP00000003760	Uncharacterized protein.	Interleukin 11.	0.978
CTF1	IL6	ENSCAFP00000024588	ENSCAFP00000053025	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.944
CTF1	IL6ST	ENSCAFP00000024588	ENSCAFP00000062759	Uncharacterized protein.	Uncharacterized protein.	0.955
CTF1	JAK1	ENSCAFP00000024588	ENSCAFP00000039978	Uncharacterized protein.	Tyrosine-protein kinase.	0.978
CTF1	JAK2	ENSCAFP00000024588	ENSCAFP00000044346	Uncharacterized protein.	Janus kinase 2.	0.979
CTF1	LIF	ENSCAFP00000024588	ENSCAFP00000036140	Uncharacterized protein.	LIF interleukin 6 family cytokine.	0.988
CTF1	LIFR	ENSCAFP00000024588	ENSCAFP00000047973	Uncharacterized protein.	Leukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity).	0.989
CTF1	LOC489915	ENSCAFP00000024588	ENSCAFP00000055558	Uncharacterized protein.	Uncharacterized protein.	0.896
CTF1	OSM	ENSCAFP00000024588	ENSCAFP00000018361	Uncharacterized protein.	Oncostatin M.	0.991
CTF1	OSMR	ENSCAFP00000024588	ENSCAFP00000027517	Uncharacterized protein.	Oncostatin M receptor.	0.905
IL11	CTF1	ENSCAFP00000003760	ENSCAFP00000024588	Interleukin 11.	Uncharacterized protein.	0.978
IL11	IL6	ENSCAFP00000003760	ENSCAFP00000053025	Interleukin 11.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.984
IL11	IL6ST	ENSCAFP00000003760	ENSCAFP00000062759	Interleukin 11.	Uncharacterized protein.	0.947
IL11	JAK1	ENSCAFP00000003760	ENSCAFP00000039978	Interleukin 11.	Tyrosine-protein kinase.	0.872
IL11	JAK2	ENSCAFP00000003760	ENSCAFP00000044346	Interleukin 11.	Janus kinase 2.	0.879
IL11	LIF	ENSCAFP00000003760	ENSCAFP00000036140	Interleukin 11.	LIF interleukin 6 family cytokine.	0.971
IL11	LIFR	ENSCAFP00000003760	ENSCAFP00000047973	Interleukin 11.	Leukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity).	0.905
IL11	LOC489915	ENSCAFP00000003760	ENSCAFP00000055558	Interleukin 11.	Uncharacterized protein.	0.878
IL11	OSM	ENSCAFP00000003760	ENSCAFP00000018361	Interleukin 11.	Oncostatin M.	0.980
IL11	OSMR	ENSCAFP00000003760	ENSCAFP00000027517	Interleukin 11.	Oncostatin M receptor.	0.863