Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RAB8ARas-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa)    
Predicted Functional Partners:
RILPL2
Rab interacting lysosomal protein like 2.
   
 
 0.917
WDR41
WD repeat domain 41.
     
 0.888
RABIF
RAB interacting factor.
   
 
 0.888
RILPL1
Rab interacting lysosomal protein like 1.
    
 0.886
TBC1D1
TBC1 domain family member 1.
    
 0.875
SMCR8
SMCR8-C9orf72 complex subunit.
    
 0.872
C11H9orf72
Chromosome 11 C9orf72 homolog.
    
 0.865
MICALL2
MICAL like 2.
    
 0.859
CEP290
Centrosomal protein 290.
    
 
 0.836
RAB3IP
RAB3A interacting protein.
    
 
 0.836
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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