BCL2L11 protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

BCL2L11

BCL2 like 11. (301 aa)

Predicted Functional Partners:

BCL2L1

0.998

BCL2

0.997

MCL1

0.997

DYNLL1

0.977

BAK1

0.973

PMAIP1

0.969

BAX

0.949

BBC3

0.940

MAPK1

0.939

BAD

0.927

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAD	BAK1	ENSCAFP00000034035	ENSCAFP00000001448	BCL2 associated agonist of cell death.	BCL2 antagonist/killer 1.	0.872
BAD	BAX	ENSCAFP00000034035	ENSCAFP00000005763	BCL2 associated agonist of cell death.	BCL2 associated X, apoptosis regulator.	0.862
BAD	BBC3	ENSCAFP00000034035	ENSCAFP00000054385	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.409
BAD	BCL2	ENSCAFP00000034035	ENSCAFP00000000102	BCL2 associated agonist of cell death.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	0.997
BAD	BCL2L1	ENSCAFP00000034035	ENSCAFP00000010478	BCL2 associated agonist of cell death.	BCL2 like 1.	0.997
BAD	BCL2L11	ENSCAFP00000034035	ENSCAFP00000046855	BCL2 associated agonist of cell death.	BCL2 like 11.	0.927
BAD	MAPK1	ENSCAFP00000034035	ENSCAFP00000030998	BCL2 associated agonist of cell death.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.893
BAD	MCL1	ENSCAFP00000034035	ENSCAFP00000017738	BCL2 associated agonist of cell death.	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity); Belongs to the Bcl-2 family.	0.618
BAD	PMAIP1	ENSCAFP00000034035	ENSCAFP00000032282	BCL2 associated agonist of cell death.	Phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity). Belongs to the PMAIP1 family.	0.652
BAK1	BAD	ENSCAFP00000001448	ENSCAFP00000034035	BCL2 antagonist/killer 1.	BCL2 associated agonist of cell death.	0.872
BAK1	BAX	ENSCAFP00000001448	ENSCAFP00000005763	BCL2 antagonist/killer 1.	BCL2 associated X, apoptosis regulator.	0.972
BAK1	BBC3	ENSCAFP00000001448	ENSCAFP00000054385	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.742
BAK1	BCL2	ENSCAFP00000001448	ENSCAFP00000000102	BCL2 antagonist/killer 1.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	0.989
BAK1	BCL2L1	ENSCAFP00000001448	ENSCAFP00000010478	BCL2 antagonist/killer 1.	BCL2 like 1.	0.995
BAK1	BCL2L11	ENSCAFP00000001448	ENSCAFP00000046855	BCL2 antagonist/killer 1.	BCL2 like 11.	0.973
BAK1	MCL1	ENSCAFP00000001448	ENSCAFP00000017738	BCL2 antagonist/killer 1.	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity); Belongs to the Bcl-2 family.	0.940
BAK1	PMAIP1	ENSCAFP00000001448	ENSCAFP00000032282	BCL2 antagonist/killer 1.	Phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity). Belongs to the PMAIP1 family.	0.819
BAX	BAD	ENSCAFP00000005763	ENSCAFP00000034035	BCL2 associated X, apoptosis regulator.	BCL2 associated agonist of cell death.	0.862
BAX	BAK1	ENSCAFP00000005763	ENSCAFP00000001448	BCL2 associated X, apoptosis regulator.	BCL2 antagonist/killer 1.	0.972
BAX	BBC3	ENSCAFP00000005763	ENSCAFP00000054385	BCL2 associated X, apoptosis regulator.	Uncharacterized protein.	0.693