node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALOX5 | PLA2G4A | ENSCAFP00000010341 | ENSCAFP00000020325 | Arachidonate 5-lipoxygenase. | Phospholipase A2. | 0.950 |
ALOX5 | PTGS1 | ENSCAFP00000010341 | ENSCAFP00000044458 | Arachidonate 5-lipoxygenase. | Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (By similarity). | 0.937 |
ALOX5 | PTGS2 | ENSCAFP00000010341 | ENSCAFP00000020288 | Arachidonate 5-lipoxygenase. | Prostaglandin-endoperoxide synthase 2. | 0.937 |
HPGDS | PTGDS | ENSCAFP00000061205 | ENSCAFP00000046976 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] | 0.969 |
HPGDS | PTGES | ENSCAFP00000061205 | ENSCAFP00000040771 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). | 0.949 |
HPGDS | PTGES2 | ENSCAFP00000061205 | ENSCAFP00000029770 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin E synthase 2. | 0.944 |
HPGDS | PTGIS | ENSCAFP00000061205 | ENSCAFP00000016804 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin I2 synthase; Belongs to the cytochrome P450 family. | 0.943 |
HPGDS | PTGS1 | ENSCAFP00000061205 | ENSCAFP00000044458 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (By similarity). | 0.950 |
HPGDS | PTGS2 | ENSCAFP00000061205 | ENSCAFP00000020288 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin-endoperoxide synthase 2. | 0.930 |
HPGDS | TBXAS1 | ENSCAFP00000061205 | ENSCAFP00000005960 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Thromboxane A synthase 1; Belongs to the cytochrome P450 family. | 0.946 |
IL1B | PTGES | ENSCAFP00000010762 | ENSCAFP00000040771 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). | 0.578 |
IL1B | PTGS1 | ENSCAFP00000010762 | ENSCAFP00000044458 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (By similarity). | 0.564 |
IL1B | PTGS2 | ENSCAFP00000010762 | ENSCAFP00000020288 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Prostaglandin-endoperoxide synthase 2. | 0.919 |
PLA2G4A | ALOX5 | ENSCAFP00000020325 | ENSCAFP00000010341 | Phospholipase A2. | Arachidonate 5-lipoxygenase. | 0.950 |
PLA2G4A | PTGES | ENSCAFP00000020325 | ENSCAFP00000040771 | Phospholipase A2. | Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). | 0.507 |
PLA2G4A | PTGES2 | ENSCAFP00000020325 | ENSCAFP00000029770 | Phospholipase A2. | Prostaglandin E synthase 2. | 0.450 |
PLA2G4A | PTGS1 | ENSCAFP00000020325 | ENSCAFP00000044458 | Phospholipase A2. | Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (By similarity). | 0.893 |
PLA2G4A | PTGS2 | ENSCAFP00000020325 | ENSCAFP00000020288 | Phospholipase A2. | Prostaglandin-endoperoxide synthase 2. | 0.920 |
PTGDS | HPGDS | ENSCAFP00000046976 | ENSCAFP00000061205 | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | 0.969 |
PTGDS | PTGES | ENSCAFP00000046976 | ENSCAFP00000040771 | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] | Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). | 0.952 |