Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSCAFP00000040898Cathepsin L1 Cathepsin L1 heavy chain Cathepsin L1 light chain. (333 aa)    
Predicted Functional Partners:
CD74
CD74 molecule.
   
 0.830
CTSH
Cathepsin H; Belongs to the peptidase C1 family.
    
 0.821
CTSB
Cathepsin B; Belongs to the peptidase C1 family.
  
0.820
CTSZ
Cathepsin Z; Belongs to the peptidase C1 family.
  
0.775
CTSA
Carboxypeptidase; Belongs to the peptidase S10 family.
   
 0.771
CTSD
Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.
   
 0.760
CTSS
Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity).
   
  0.711
CTSK
Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
   
  0.711
CTSO
Cathepsin O; Belongs to the peptidase C1 family.
  
0.707
CTSE
Cathepsin E; Belongs to the peptidase A1 family.
   
 0.706
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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