node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL15 | IL2 | ENSCAFP00000005401 | ENSCAFP00000005941 | Interleukin; Belongs to the IL-15/IL-21 family. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.931 |
IL15 | IL21R | ENSCAFP00000005401 | ENSCAFP00000037398 | Interleukin; Belongs to the IL-15/IL-21 family. | Interleukin 21 receptor. | 0.833 |
IL15 | IL2RA | ENSCAFP00000005401 | ENSCAFP00000007785 | Interleukin; Belongs to the IL-15/IL-21 family. | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. | 0.835 |
IL15 | IL2RB | ENSCAFP00000005401 | ENSCAFP00000002178 | Interleukin; Belongs to the IL-15/IL-21 family. | Fibronectin type-III domain-containing protein. | 0.994 |
IL15 | IL2RG | ENSCAFP00000005401 | ENSCAFP00000041465 | Interleukin; Belongs to the IL-15/IL-21 family. | Cytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Belongs to the type I cytokine receptor family. Type 5 subfamily. | 0.996 |
IL15 | IL4 | ENSCAFP00000005401 | ENSCAFP00000001253 | Interleukin; Belongs to the IL-15/IL-21 family. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.884 |
IL15 | IL7 | ENSCAFP00000005401 | ENSCAFP00000012305 | Interleukin; Belongs to the IL-15/IL-21 family. | Interleukin 7. | 0.923 |
IL15 | IL9 | ENSCAFP00000005401 | ENSCAFP00000056083 | Interleukin; Belongs to the IL-15/IL-21 family. | Interleukin 9. | 0.869 |
IL15 | JAK1 | ENSCAFP00000005401 | ENSCAFP00000039978 | Interleukin; Belongs to the IL-15/IL-21 family. | Tyrosine-protein kinase. | 0.794 |
IL15 | JAK3 | ENSCAFP00000005401 | ENSCAFP00000041505 | Interleukin; Belongs to the IL-15/IL-21 family. | Tyrosine-protein kinase. | 0.878 |
IL2 | IL15 | ENSCAFP00000005941 | ENSCAFP00000005401 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | Interleukin; Belongs to the IL-15/IL-21 family. | 0.931 |
IL2 | IL21R | ENSCAFP00000005941 | ENSCAFP00000037398 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | Interleukin 21 receptor. | 0.820 |
IL2 | IL2RA | ENSCAFP00000005941 | ENSCAFP00000007785 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. | 0.996 |
IL2 | IL2RB | ENSCAFP00000005941 | ENSCAFP00000002178 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | Fibronectin type-III domain-containing protein. | 0.995 |
IL2 | IL2RG | ENSCAFP00000005941 | ENSCAFP00000041465 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | Cytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Belongs to the type I cytokine receptor family. Type 5 subfamily. | 0.998 |
IL2 | IL4 | ENSCAFP00000005941 | ENSCAFP00000001253 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.973 |
IL2 | IL7 | ENSCAFP00000005941 | ENSCAFP00000012305 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | Interleukin 7. | 0.927 |
IL2 | IL9 | ENSCAFP00000005941 | ENSCAFP00000056083 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | Interleukin 9. | 0.888 |
IL2 | JAK1 | ENSCAFP00000005941 | ENSCAFP00000039978 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | Tyrosine-protein kinase. | 0.962 |
IL2 | JAK3 | ENSCAFP00000005941 | ENSCAFP00000041505 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | Tyrosine-protein kinase. | 0.980 |