STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC100049001Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type; Belongs to the peptidase S1 family. Tryptase subfamily. (494 aa)    
Predicted Functional Partners:
CMA1
Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
  
 
0.685
KLK10
Kallikrein related peptidase 10; Belongs to the peptidase S1 family.
  
    0.538
KLK6
Kallikrein related peptidase 6; Belongs to the peptidase S1 family.
  
     0.535
CTSG
Granzyme B; Belongs to the peptidase S1 family.
  
 
0.534
J9NXN6_CANLF
Uncharacterized protein; Belongs to the peptidase S1 family.
  
     0.532
CPA3
Carboxypeptidase B.
   
 
 0.520
RB1
RB transcriptional corepressor 1.
    
 
 0.515
ENSCAFP00000047054
Peptidase S1 domain-containing protein.
  
 
   0.501
ELANE
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
  
 
0.499
CBX2
Chromobox 2.
      
 0.487
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: medium (56%) [HD]