GRB2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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experimentally determined

co-expression

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gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

GRB2

Growth factor receptor bound protein 2. (250 aa)

Predicted Functional Partners:

EGFR

0.999

GAB1

0.999

SOS1

0.999

SOS2

0.999

PTK2

0.999

LCP2

0.998

FRS2

0.997

SHC1

0.997

LAT

0.997

PTPN11

0.996

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	GAB1	ENSCAFP00000005164	ENSCAFP00000005384	Receptor protein-tyrosine kinase.	GRB2 associated binding protein 1.	0.996
EGFR	GRB2	ENSCAFP00000005164	ENSCAFP00000049390	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.999
EGFR	LAT	ENSCAFP00000005164	ENSCAFP00000025545	Receptor protein-tyrosine kinase.	Linker for activation of T cells.	0.787
EGFR	LCP2	ENSCAFP00000005164	ENSCAFP00000040724	Receptor protein-tyrosine kinase.	Lymphocyte cytosolic protein 2.	0.792
EGFR	PTK2	ENSCAFP00000005164	ENSCAFP00000051882	Receptor protein-tyrosine kinase.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.994
EGFR	PTPN11	ENSCAFP00000005164	ENSCAFP00000013074	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.992
EGFR	SHC1	ENSCAFP00000005164	ENSCAFP00000025262	Receptor protein-tyrosine kinase.	SHC adaptor protein 1.	0.985
EGFR	SOS1	ENSCAFP00000005164	ENSCAFP00000009512	Receptor protein-tyrosine kinase.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.997
EGFR	SOS2	ENSCAFP00000005164	ENSCAFP00000021080	Receptor protein-tyrosine kinase.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.993
FRS2	GAB1	ENSCAFP00000000625	ENSCAFP00000005384	Fibroblast growth factor receptor substrate 2.	GRB2 associated binding protein 1.	0.690
FRS2	GRB2	ENSCAFP00000000625	ENSCAFP00000049390	Fibroblast growth factor receptor substrate 2.	Growth factor receptor bound protein 2.	0.997
FRS2	PTPN11	ENSCAFP00000000625	ENSCAFP00000013074	Fibroblast growth factor receptor substrate 2.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.927
FRS2	SOS1	ENSCAFP00000000625	ENSCAFP00000009512	Fibroblast growth factor receptor substrate 2.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.935
FRS2	SOS2	ENSCAFP00000000625	ENSCAFP00000021080	Fibroblast growth factor receptor substrate 2.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.582
GAB1	EGFR	ENSCAFP00000005384	ENSCAFP00000005164	GRB2 associated binding protein 1.	Receptor protein-tyrosine kinase.	0.996
GAB1	FRS2	ENSCAFP00000005384	ENSCAFP00000000625	GRB2 associated binding protein 1.	Fibroblast growth factor receptor substrate 2.	0.690
GAB1	GRB2	ENSCAFP00000005384	ENSCAFP00000049390	GRB2 associated binding protein 1.	Growth factor receptor bound protein 2.	0.999
GAB1	PTPN11	ENSCAFP00000005384	ENSCAFP00000013074	GRB2 associated binding protein 1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.989
GAB1	SHC1	ENSCAFP00000005384	ENSCAFP00000025262	GRB2 associated binding protein 1.	SHC adaptor protein 1.	0.984
GAB1	SOS1	ENSCAFP00000005384	ENSCAFP00000009512	GRB2 associated binding protein 1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.967