| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1C3 | CYP8B1 | ENSCAFP00000007901 | ENSCAFP00000008003 | Aldo_ket_red domain-containing protein. | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.681 |
| AKR1C3 | HPGDS | ENSCAFP00000007901 | ENSCAFP00000061205 | Aldo_ket_red domain-containing protein. | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | 0.929 |
| AKR1C3 | PTGDS | ENSCAFP00000007901 | ENSCAFP00000046976 | Aldo_ket_red domain-containing protein. | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] | 0.815 |
| AKR1C3 | PTGES | ENSCAFP00000007901 | ENSCAFP00000040771 | Aldo_ket_red domain-containing protein. | Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). | 0.695 |
| AKR1C3 | PTGS2 | ENSCAFP00000007901 | ENSCAFP00000020288 | Aldo_ket_red domain-containing protein. | Prostaglandin-endoperoxide synthase 2. | 0.473 |
| AKR1C3 | TBXAS1 | ENSCAFP00000007901 | ENSCAFP00000005960 | Aldo_ket_red domain-containing protein. | Thromboxane A synthase 1; Belongs to the cytochrome P450 family. | 0.402 |
| CYP8B1 | AKR1C3 | ENSCAFP00000008003 | ENSCAFP00000007901 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. | Aldo_ket_red domain-containing protein. | 0.681 |
| CYP8B1 | HPGDS | ENSCAFP00000008003 | ENSCAFP00000061205 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | 0.761 |
| CYP8B1 | PRXL2B | ENSCAFP00000008003 | ENSCAFP00000050851 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. | Peroxiredoxin like 2B. | 0.707 |
| CYP8B1 | PTGDS | ENSCAFP00000008003 | ENSCAFP00000046976 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] | 0.740 |
| CYP8B1 | PTGES | ENSCAFP00000008003 | ENSCAFP00000040771 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. | Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). | 0.753 |
| CYP8B1 | PTGES2 | ENSCAFP00000008003 | ENSCAFP00000029770 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. | Prostaglandin E synthase 2. | 0.753 |
| CYP8B1 | PTGS1 | ENSCAFP00000008003 | ENSCAFP00000044458 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. | Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (By similarity). | 0.747 |
| CYP8B1 | PTGS2 | ENSCAFP00000008003 | ENSCAFP00000020288 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. | Prostaglandin-endoperoxide synthase 2. | 0.753 |
| CYP8B1 | TBXAS1 | ENSCAFP00000008003 | ENSCAFP00000005960 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. | Thromboxane A synthase 1; Belongs to the cytochrome P450 family. | 0.736 |
| HPGDS | AKR1C3 | ENSCAFP00000061205 | ENSCAFP00000007901 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Aldo_ket_red domain-containing protein. | 0.929 |
| HPGDS | CYP8B1 | ENSCAFP00000061205 | ENSCAFP00000008003 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.761 |
| HPGDS | PRXL2B | ENSCAFP00000061205 | ENSCAFP00000050851 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Peroxiredoxin like 2B. | 0.841 |
| HPGDS | PTGDS | ENSCAFP00000061205 | ENSCAFP00000046976 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] | 0.975 |
| HPGDS | PTGES | ENSCAFP00000061205 | ENSCAFP00000040771 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). | 0.926 |
