STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TMX3Thioredoxin related transmembrane protein 3. (453 aa)    
Predicted Functional Partners:
TMX1
Thioredoxin related transmembrane protein 1.
   
 
 0.764
TMX4
Thioredoxin related transmembrane protein 4.
   
 
 0.620
CANX
Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...]
   
 
 0.613
UNC50
Unc-50 inner nuclear membrane RNA binding protein.
      
 0.597
SCCPDH
Saccharopine dehydrogenase (putative).
      
 0.576
SUOX
Sulfite oxidase.
    
 0.572
TMX2
Thioredoxin related transmembrane protein 2.
    
 
 0.545
NOXO1
NADPH oxidase organizer 1.
    
 
 0.534
AKR7L
Aldo-keto reductase family 7 like (gene/pseudogene).
    
 
 0.532
EMC6
ER membrane protein complex subunit 6.
      
 0.483
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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