STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SERPINB13Serpin family B member 13; Belongs to the serpin family. (433 aa)    
Predicted Functional Partners:
CTSG
Granzyme B; Belongs to the peptidase S1 family.
   
 0.920
LOC102156614
Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.
   
 0.736
CTSK
Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
    
 0.722
CTSL3
Uncharacterized protein; Belongs to the peptidase C1 family.
    
 0.720
KAT14
Lysine acetyltransferase 14.
    
 
 0.639
KLK13
Kallikrein related peptidase 13; Belongs to the peptidase S1 family.
   
 
 0.593
ZNF34
Zinc finger protein 34.
    
 
 0.520
ZNF250
Zinc finger protein 250.
    
 
 0.520
SERPING1
Serpin family G member 1; Belongs to the serpin family.
  
   0.510
PACSIN3
Protein kinase C and casein kinase substrate in neurons 3.
      
 0.502
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.