STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SERPINB12Serpin family B member 12; Belongs to the serpin family. (423 aa)    
Predicted Functional Partners:
HEPACAM
Hepatic and glial cell adhesion molecule.
      
 0.769
KLK13
Kallikrein related peptidase 13; Belongs to the peptidase S1 family.
   
 
 0.720
HEPACAM2
HEPACAM family member 2.
      
 0.717
CASP14
Caspase 14; Belongs to the peptidase C14A family.
   
 
 0.715
SBSN
Uncharacterized protein.
      
 0.694
PNLIPRP3
Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.
    
 
 0.662
CSTA
Cystatin A; Belongs to the cystatin family.
   
 
 0.605
KLK6
Kallikrein related peptidase 6; Belongs to the peptidase S1 family.
   
 
 0.565
KLK5
Kallikrein related peptidase 5; Belongs to the peptidase S1 family.
   
 
 0.565
LGALS3
Galectin-3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage [...]
     
 0.559
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.