STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRYD4SPRY domain containing 4. (254 aa)    
Predicted Functional Partners:
MIP
Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.843
GLS2
Glutaminase 2.
   
  
 0.789
CCNT1
Cyclin T1; Belongs to the cyclin family.
   
 
 0.759
YEATS4
YEATS domain containing 4.
   
  
 0.748
LYZL4
Lysozyme like 4.
      
 0.676
TMEM192
Transmembrane protein 192.
   
   0.660
NUP107
Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).
    
 
 0.564
YIF1B
Yip1 interacting factor homolog B, membrane trafficking protein.
   
  
 0.562
ARMCX3
Armadillo repeat containing X-linked 3.
   
 
 0.526
CPPED1
Calcineurin like phosphoesterase domain containing 1.
   
  
 0.522
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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