STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRHDEThyrotropin releasing hormone degrading enzyme. (1005 aa)    
Predicted Functional Partners:
CAMKMT
Calmodulin-lysine N-methyltransferase.
    
 
 0.783
RFXANK
Regulatory factor X associated ankyrin containing protein.
    
 
 0.651
TBCB
Tubulin folding cofactor B.
      
 0.616
GHITM
Growth hormone inducible transmembrane protein; Belongs to the BI1 family.
      
 0.575
MEF2B
MADS-box domain-containing protein.
      
 0.570
MBD5
Methyl-CpG binding domain protein 5.
   
 
 0.567
TRH
Thyrotropin releasing hormone.
      
 0.560
ADGRL3
Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.
   
 
 0.536
TLL1
Metalloendopeptidase.
      
 0.517
RIPK2
Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.
      
 0.507
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.