STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM181Transmembrane protein 181. (605 aa)    
Predicted Functional Partners:
DYNLT1
Dynein light chain Tctex-type 1.
    
 
 0.733
DYNLT3
Dynein light chain Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).
    
 
 0.680
CACUL1
CDK2 associated cullin domain 1; Belongs to the cullin family.
   
  
 0.656
TRIO
Trio Rho guanine nucleotide exchange factor.
   
 
 0.652
TAGAP
T cell activation RhoGTPase activating protein.
      
 0.570
SGMS1
Sphingomyelin synthase 1.
   
  
 0.569
ARID1B
AT-rich interaction domain 1B.
      
 0.561
ADGRL3
Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.
   
 
 0.525
NOX3
Predicted NADPH oxidase-3.
      
 0.499
LOC609777
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
      
 0.499
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.