STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CRELD2Cysteine rich with EGF like domains 2. (391 aa)    
Predicted Functional Partners:
SDF2L1
Stromal cell derived factor 2 like 1.
   
 
 0.910
MANF
Mesencephalic astrocyte derived neurotrophic factor.
   
  
 0.909
GMPPB
GDP-mannose pyrophosphorylase B.
   
  
 0.883
PDIA4
Protein disulfide isomerase family A member 4; Belongs to the protein disulfide isomerase family.
   
  
 0.839
RIMKLB
Ribosomal modification protein rimK like family member B.
      
 0.806
TM4SF1
Transmembrane 4 L six family member 1.
      
 0.789
DNAJB11
DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.
   
 
 0.783
HYOU1
Hypoxia up-regulated 1.
   
 
 0.773
MATN3
Matrilin 3.
    
 
 0.722
PDIA6
Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family.
   
  
 0.717
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.