CRELD2 protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

CRELD2

Cysteine rich with EGF like domains 2. (391 aa)

Predicted Functional Partners:

SDF2L1

0.932

MANF

0.920

DNAJB11

0.917

PDIA4

0.903

GMPPB

0.846

HYOU1

0.845

PDIA6

0.804

RIMKLB

0.778

HSPA5

0.735

SUPV3L1

0.665

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRELD2	DNAJB11	ENSCAFP00000001013	ENSCAFP00000041977	Cysteine rich with EGF like domains 2.	DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.	0.917
CRELD2	GMPPB	ENSCAFP00000001013	ENSCAFP00000032143	Cysteine rich with EGF like domains 2.	GDP-mannose pyrophosphorylase B.	0.846
CRELD2	HSPA5	ENSCAFP00000001013	ENSCAFP00000029957	Cysteine rich with EGF like domains 2.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.735
CRELD2	HYOU1	ENSCAFP00000001013	ENSCAFP00000054908	Cysteine rich with EGF like domains 2.	Hypoxia up-regulated 1.	0.845
CRELD2	MANF	ENSCAFP00000001013	ENSCAFP00000015071	Cysteine rich with EGF like domains 2.	Mesencephalic astrocyte derived neurotrophic factor.	0.920
CRELD2	PDIA4	ENSCAFP00000001013	ENSCAFP00000056407	Cysteine rich with EGF like domains 2.	Protein disulfide isomerase family A member 4; Belongs to the protein disulfide isomerase family.	0.903
CRELD2	PDIA6	ENSCAFP00000001013	ENSCAFP00000064087	Cysteine rich with EGF like domains 2.	Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family.	0.804
CRELD2	RIMKLB	ENSCAFP00000001013	ENSCAFP00000020456	Cysteine rich with EGF like domains 2.	Ribosomal modification protein rimK like family member B.	0.778
CRELD2	SDF2L1	ENSCAFP00000001013	ENSCAFP00000022567	Cysteine rich with EGF like domains 2.	Stromal cell derived factor 2 like 1.	0.932
CRELD2	SUPV3L1	ENSCAFP00000001013	ENSCAFP00000020394	Cysteine rich with EGF like domains 2.	Suv3 like RNA helicase.	0.665
DNAJB11	CRELD2	ENSCAFP00000041977	ENSCAFP00000001013	DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.	Cysteine rich with EGF like domains 2.	0.917
DNAJB11	HSPA5	ENSCAFP00000041977	ENSCAFP00000029957	DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.995
DNAJB11	HYOU1	ENSCAFP00000041977	ENSCAFP00000054908	DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.	Hypoxia up-regulated 1.	0.844
DNAJB11	MANF	ENSCAFP00000041977	ENSCAFP00000015071	DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.	Mesencephalic astrocyte derived neurotrophic factor.	0.901
DNAJB11	PDIA4	ENSCAFP00000041977	ENSCAFP00000056407	DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.	Protein disulfide isomerase family A member 4; Belongs to the protein disulfide isomerase family.	0.718
DNAJB11	PDIA6	ENSCAFP00000041977	ENSCAFP00000064087	DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.	Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family.	0.931
DNAJB11	SDF2L1	ENSCAFP00000041977	ENSCAFP00000022567	DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.	Stromal cell derived factor 2 like 1.	0.913
GMPPB	CRELD2	ENSCAFP00000032143	ENSCAFP00000001013	GDP-mannose pyrophosphorylase B.	Cysteine rich with EGF like domains 2.	0.846
GMPPB	HSPA5	ENSCAFP00000032143	ENSCAFP00000029957	GDP-mannose pyrophosphorylase B.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.683
GMPPB	MANF	ENSCAFP00000032143	ENSCAFP00000015071	GDP-mannose pyrophosphorylase B.	Mesencephalic astrocyte derived neurotrophic factor.	0.710