RAPGEF6 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RAPGEF6

Uncharacterized protein. (1614 aa)

Predicted Functional Partners:

RAP1B

0.955

RAP1A

0.955

MAGI2

0.926

MAGI3

0.920

F11R

0.908

RAPGEF2

0.901

PTPN13

0.737

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F11R	RAPGEF6	ENSCAFP00000018655	ENSCAFP00000001071	F11 receptor.	Uncharacterized protein.	0.908
MAGI2	MAGI3	ENSCAFP00000006489	ENSCAFP00000019378	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	Membrane associated guanylate kinase, WW and PDZ domain containing 3.	0.913
MAGI2	RAPGEF2	ENSCAFP00000006489	ENSCAFP00000066461	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	0.939
MAGI2	RAPGEF6	ENSCAFP00000006489	ENSCAFP00000001071	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	Uncharacterized protein.	0.926
MAGI3	MAGI2	ENSCAFP00000019378	ENSCAFP00000006489	Membrane associated guanylate kinase, WW and PDZ domain containing 3.	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	0.913
MAGI3	RAPGEF2	ENSCAFP00000019378	ENSCAFP00000066461	Membrane associated guanylate kinase, WW and PDZ domain containing 3.	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	0.920
MAGI3	RAPGEF6	ENSCAFP00000019378	ENSCAFP00000001071	Membrane associated guanylate kinase, WW and PDZ domain containing 3.	Uncharacterized protein.	0.920
PTPN13	RAPGEF2	ENSCAFP00000013880	ENSCAFP00000066461	Protein tyrosine phosphatase non-receptor type 13.	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	0.634
PTPN13	RAPGEF6	ENSCAFP00000013880	ENSCAFP00000001071	Protein tyrosine phosphatase non-receptor type 13.	Uncharacterized protein.	0.737
RAP1A	RAP1B	ENSCAFP00000040927	ENSCAFP00000000596	RAP1A, member of RAS oncogene family.	RAP1B, member of RAS oncogene family.	0.934
RAP1A	RAPGEF2	ENSCAFP00000040927	ENSCAFP00000066461	RAP1A, member of RAS oncogene family.	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	0.968
RAP1A	RAPGEF6	ENSCAFP00000040927	ENSCAFP00000001071	RAP1A, member of RAS oncogene family.	Uncharacterized protein.	0.955
RAP1B	RAP1A	ENSCAFP00000000596	ENSCAFP00000040927	RAP1B, member of RAS oncogene family.	RAP1A, member of RAS oncogene family.	0.934
RAP1B	RAPGEF2	ENSCAFP00000000596	ENSCAFP00000066461	RAP1B, member of RAS oncogene family.	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	0.970
RAP1B	RAPGEF6	ENSCAFP00000000596	ENSCAFP00000001071	RAP1B, member of RAS oncogene family.	Uncharacterized protein.	0.955
RAPGEF2	MAGI2	ENSCAFP00000066461	ENSCAFP00000006489	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	0.939
RAPGEF2	MAGI3	ENSCAFP00000066461	ENSCAFP00000019378	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	Membrane associated guanylate kinase, WW and PDZ domain containing 3.	0.920
RAPGEF2	PTPN13	ENSCAFP00000066461	ENSCAFP00000013880	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	Protein tyrosine phosphatase non-receptor type 13.	0.634
RAPGEF2	RAP1A	ENSCAFP00000066461	ENSCAFP00000040927	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	RAP1A, member of RAS oncogene family.	0.968
RAPGEF2	RAP1B	ENSCAFP00000066461	ENSCAFP00000000596	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	RAP1B, member of RAS oncogene family.	0.970