RNF5 protein (Canis lupus familiaris) - STRING interaction network

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Score

RNF5

Ring finger protein 5. (180 aa)

Predicted Functional Partners:

DERL1

0.930

ERLIN2

0.919

SEL1L

0.915

CFTR

0.893

TMUB1

0.893

ERLIN1

0.876

TMEM259

0.829

AMFR

0.822

STING1

0.789

UBE2K

0.757

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMFR	CFTR	ENSCAFP00000013489	ENSCAFP00000005112	Autocrine motility factor receptor.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	0.638
AMFR	DERL1	ENSCAFP00000013489	ENSCAFP00000001384	Autocrine motility factor receptor.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.982
AMFR	ERLIN1	ENSCAFP00000013489	ENSCAFP00000014077	Autocrine motility factor receptor.	ER lipid raft associated 1.	0.844
AMFR	ERLIN2	ENSCAFP00000013489	ENSCAFP00000009309	Autocrine motility factor receptor.	ER lipid raft associated 2.	0.938
AMFR	RNF5	ENSCAFP00000013489	ENSCAFP00000001106	Autocrine motility factor receptor.	Ring finger protein 5.	0.822
AMFR	SEL1L	ENSCAFP00000013489	ENSCAFP00000056064	Autocrine motility factor receptor.	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.	0.922
AMFR	TMUB1	ENSCAFP00000013489	ENSCAFP00000007076	Autocrine motility factor receptor.	Transmembrane and ubiquitin like domain containing 1.	0.664
AMFR	UBE2K	ENSCAFP00000013489	ENSCAFP00000023490	Autocrine motility factor receptor.	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	0.444
CFTR	AMFR	ENSCAFP00000005112	ENSCAFP00000013489	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Autocrine motility factor receptor.	0.638
CFTR	DERL1	ENSCAFP00000005112	ENSCAFP00000001384	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.934
CFTR	ERLIN1	ENSCAFP00000005112	ENSCAFP00000014077	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	ER lipid raft associated 1.	0.510
CFTR	ERLIN2	ENSCAFP00000005112	ENSCAFP00000009309	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	ER lipid raft associated 2.	0.515
CFTR	RNF5	ENSCAFP00000005112	ENSCAFP00000001106	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Ring finger protein 5.	0.893
CFTR	SEL1L	ENSCAFP00000005112	ENSCAFP00000056064	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.	0.549
DERL1	AMFR	ENSCAFP00000001384	ENSCAFP00000013489	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Autocrine motility factor receptor.	0.982
DERL1	CFTR	ENSCAFP00000001384	ENSCAFP00000005112	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	0.934
DERL1	ERLIN1	ENSCAFP00000001384	ENSCAFP00000014077	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	ER lipid raft associated 1.	0.593
DERL1	ERLIN2	ENSCAFP00000001384	ENSCAFP00000009309	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	ER lipid raft associated 2.	0.641
DERL1	RNF5	ENSCAFP00000001384	ENSCAFP00000001106	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ring finger protein 5.	0.930
DERL1	SEL1L	ENSCAFP00000001384	ENSCAFP00000056064	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.	0.970