STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOTCH4Notch receptor 4. (1773 aa)    
Predicted Functional Partners:
JAG1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
 
0.945
DLL4
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
 
0.944
JAG2
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
 
0.940
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
    
 0.929
CREBBP
CREB binding protein.
    
 0.826
DLL1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
 
0.820
SNW1
SNW domain containing 1.
    
 0.815
MAML1
Mastermind like transcriptional coactivator 1.
   
 0.803
HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]
   
 
 0.777
AKT1
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.776
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.