STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC100856021Uncharacterized protein. (568 aa)    
Predicted Functional Partners:
CTNND2
Catenin delta 2.
    
 
 0.691
ADAMTS16
ADAM metallopeptidase with thrombospondin type 1 motif 16.
      
 0.689
ICOS
Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...]
   
 0.464
ADGRG1
Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family.
    
 
 0.463
RNF128
Ring finger protein 128.
      
 0.463
ANKRD11
Ankyrin repeat domain 11.
    
 0.452
DDX58
DExD/H-box helicase 58.
   
 0.442
TRIM10
Tripartite motif containing 10.
   
 
 0.420
HLA-DQB1
Major histocompatibility complex, class II, DQ beta 2.
   
 
 0.413
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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