DLA-DQA1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DLA-DQA1

Ig-like domain-containing protein; Belongs to the MHC class II family. (344 aa)

Predicted Functional Partners:

CD74

0.996

F1PSQ5_CANLF

0.982

HLA-DQB2

0.944

DLA-DRA

0.943

DLA-DMA

0.940

HLA-DQB1

0.915

CD4

0.892

DLA-79

0.887

CD247

0.883

DLA-12

0.853

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD247	CD4	ENSCAFP00000041707	ENSCAFP00000063394	Uncharacterized protein.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.623
CD247	DLA-12	ENSCAFP00000041707	ENSCAFP00000031410	Uncharacterized protein.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.518
CD247	DLA-79	ENSCAFP00000041707	ENSCAFP00000065183	Uncharacterized protein.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.560
CD247	DLA-DMA	ENSCAFP00000041707	ENSCAFP00000001218	Uncharacterized protein.	MHC class II antigen DM alpha; Belongs to the MHC class II family.	0.881
CD247	DLA-DQA1	ENSCAFP00000041707	ENSCAFP00000001164	Uncharacterized protein.	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.883
CD247	DLA-DRA	ENSCAFP00000041707	ENSCAFP00000045482	Uncharacterized protein.	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.940
CD247	F1PSQ5_CANLF	ENSCAFP00000041707	ENSCAFP00000001282	Uncharacterized protein.	Uncharacterized protein.	0.844
CD247	HLA-DQB1	ENSCAFP00000041707	ENSCAFP00000001171	Uncharacterized protein.	Major histocompatibility complex, class II, DQ beta 2.	0.787
CD247	HLA-DQB2	ENSCAFP00000041707	ENSCAFP00000001156	Uncharacterized protein.	Major histocompatibility complex, class II, DQ beta 1.	0.846
CD4	CD247	ENSCAFP00000063394	ENSCAFP00000041707	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Uncharacterized protein.	0.623
CD4	CD74	ENSCAFP00000063394	ENSCAFP00000045678	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	CD74 molecule.	0.523
CD4	DLA-79	ENSCAFP00000063394	ENSCAFP00000065183	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.419
CD4	DLA-DMA	ENSCAFP00000063394	ENSCAFP00000001218	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	MHC class II antigen DM alpha; Belongs to the MHC class II family.	0.861
CD4	DLA-DQA1	ENSCAFP00000063394	ENSCAFP00000001164	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.892
CD4	DLA-DRA	ENSCAFP00000063394	ENSCAFP00000045482	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.978
CD4	F1PSQ5_CANLF	ENSCAFP00000063394	ENSCAFP00000001282	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Uncharacterized protein.	0.885
CD4	HLA-DQB1	ENSCAFP00000063394	ENSCAFP00000001171	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Major histocompatibility complex, class II, DQ beta 2.	0.879
CD4	HLA-DQB2	ENSCAFP00000063394	ENSCAFP00000001156	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Major histocompatibility complex, class II, DQ beta 1.	0.820
CD74	CD4	ENSCAFP00000045678	ENSCAFP00000063394	CD74 molecule.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.523
CD74	DLA-DMA	ENSCAFP00000045678	ENSCAFP00000001218	CD74 molecule.	MHC class II antigen DM alpha; Belongs to the MHC class II family.	0.983