STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRPS1Transcriptional repressor GATA binding 1. (1285 aa)    
Predicted Functional Partners:
KRTAP3-1
Keratin associated protein 3-1.
    
 
 0.565
IGSF11
Immunoglobulin superfamily member 11.
   
  
 0.559
NFYB
Nuclear transcription factor Y subunit beta.
    
 
 0.536
HDAC4
Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
   
 
 0.524
APCDD1
APC down-regulated 1.
   
 
 0.488
LRRC14
Leucine rich repeat containing 14.
   
  
 0.486
WDR74
WD repeat domain 74.
      
 0.483
EDAR
Ectodysplasin A receptor.
      
 0.482
CLVS2
Clavesin 2.
      
 0.478
SOX18
SRY-box 18.
    
 
 0.474
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.