STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PDLIM4PDZ and LIM domain 4. (331 aa)    
Predicted Functional Partners:
PDLIM2
PDZ and LIM domain 2.
     
 0.863
PDLIM3
PDZ and LIM domain 3.
     
  0.798
TRIP6
Thyroid hormone receptor interactor 6.
    
 
 0.786
PDLIM1
PDZ and LIM domain 1.
     
  0.763
ENSCAFP00000057453
PDZ domain-containing protein.
     
  0.763
CNN3
Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
   
 
 0.722
PTPN13
Protein tyrosine phosphatase non-receptor type 13.
    
 
 0.704
RSPH1
Radial spoke head 1 homolog.
   
  
 0.699
LPP
LIM domain containing preferred translocation partner in lipoma.
    
 
 0.577
GFAP
Glial fibrillary acidic protein; Belongs to the intermediate filament family.
   
 
 0.557
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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