STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM118AFamily with sequence similarity 118 member A. (393 aa)    
Predicted Functional Partners:
WDR4
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family.
    
   0.781
RHBDD3
Rhomboid domain containing 3.
    
 0.767
LETM2
Leucine zipper and EF-hand containing transmembrane protein 2.
    
 
 0.746
THUMPD2
THUMP domain containing 2.
      
 0.738
DNAJC18
DnaJ heat shock protein family (Hsp40) member C18.
    
 
 0.736
TMEM39B
Transmembrane protein 39B.
      
 0.692
TTC38
Tetratricopeptide repeat domain 38.
      
 0.613
PLD6
Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...]
   
 0.608
UCKL1
Uridine-cytidine kinase; Belongs to the uridine kinase family.
   
 0.608
TNFSF13B
Tumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family.
    
   0.589
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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