STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DLA-DMAMHC class II antigen DM alpha; Belongs to the MHC class II family. (265 aa)    
Predicted Functional Partners:
DLA-DRA
Ig-like domain-containing protein; Belongs to the MHC class II family.
   
0.999
DLA-DOA
MHC class II antigen DO alpha; Belongs to the MHC class II family.
  
0.994
HLA-DQB2
Major histocompatibility complex, class II, DQ beta 1.
  
 0.992
CD74
CD74 molecule.
   
 0.983
HLA-DQB1
Major histocompatibility complex, class II, DQ beta 2.
   
 0.982
F1PSQ5_CANLF
Uncharacterized protein.
   
 0.968
DLA-DQA1
Ig-like domain-containing protein; Belongs to the MHC class II family.
  
0.940
J9NSQ1_CANLF
Ig-like domain-containing protein.
     
  0.909
CD247
Uncharacterized protein.
     
 0.881
CD4
T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]
     
 0.861
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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