STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RTL6Retrotransposon Gag like 6. (239 aa)    
Predicted Functional Partners:
DDIT3
DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]
    
 
 0.787
ZNF22
Zinc finger protein 22.
    
 0.700
CRACR2A
Calcium release activated channel regulator 2A.
      
 0.675
SPATC1L
Spermatogenesis and centriole associated 1 like.
      
 0.654
FANCM
FA complementation group M.
    
 0.609
BATF3
Basic leucine zipper ATF-like transcription factor 3.
    
   0.584
RTL4
Retrotransposon Gag like 4.
      
 0.571
ERC2
ELKS/RAB6-interacting/CAST family member 2.
    
 
 0.549
RTL9
Retrotransposon Gag like 9.
      
 0.542
CALHM5
Calcium homeostasis modulator family member 5.
      
 0.541
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.