DLA-DOA protein (Canis lupus familiaris) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

DLA-DOA

MHC class II antigen DO alpha; Belongs to the MHC class II family. (250 aa)

Predicted Functional Partners:

HLA-DQB2

0.935

HLA-DQB1

0.935

DLA-DRA

0.933

CD4

0.910

CD247

0.907

DLA-DMA

0.814

TAP1

0.745

DLA88

0.588

B2M

0.569

DLA-79

0.494

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	CD247	ENSCAFP00000047956	ENSCAFP00000041707	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Uncharacterized protein.	0.444
B2M	CD4	ENSCAFP00000047956	ENSCAFP00000063394	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.549
B2M	DLA-79	ENSCAFP00000047956	ENSCAFP00000065183	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.769
B2M	DLA-DMA	ENSCAFP00000047956	ENSCAFP00000001218	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	MHC class II antigen DM alpha; Belongs to the MHC class II family.	0.551
B2M	DLA-DOA	ENSCAFP00000047956	ENSCAFP00000001280	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	MHC class II antigen DO alpha; Belongs to the MHC class II family.	0.569
B2M	DLA-DRA	ENSCAFP00000047956	ENSCAFP00000045482	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.638
B2M	DLA88	ENSCAFP00000047956	ENSCAFP00000000716	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	DLA class I histocompatibility antigen, A9/A9 alpha chain; Involved in the presentation of foreign antigens to the immune system.	0.995
B2M	TAP1	ENSCAFP00000047956	ENSCAFP00000064521	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Uncharacterized protein.	0.793
CD247	B2M	ENSCAFP00000041707	ENSCAFP00000047956	Uncharacterized protein.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	0.444
CD247	CD4	ENSCAFP00000041707	ENSCAFP00000063394	Uncharacterized protein.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.717
CD247	DLA-79	ENSCAFP00000041707	ENSCAFP00000065183	Uncharacterized protein.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.651
CD247	DLA-DOA	ENSCAFP00000041707	ENSCAFP00000001280	Uncharacterized protein.	MHC class II antigen DO alpha; Belongs to the MHC class II family.	0.907
CD247	DLA-DRA	ENSCAFP00000041707	ENSCAFP00000045482	Uncharacterized protein.	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.917
CD247	DLA88	ENSCAFP00000041707	ENSCAFP00000000716	Uncharacterized protein.	DLA class I histocompatibility antigen, A9/A9 alpha chain; Involved in the presentation of foreign antigens to the immune system.	0.651
CD247	HLA-DQB1	ENSCAFP00000041707	ENSCAFP00000001171	Uncharacterized protein.	Major histocompatibility complex, class II, DQ beta 2.	0.910
CD247	HLA-DQB2	ENSCAFP00000041707	ENSCAFP00000001156	Uncharacterized protein.	Major histocompatibility complex, class II, DQ beta 1.	0.910
CD4	B2M	ENSCAFP00000063394	ENSCAFP00000047956	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	0.549
CD4	CD247	ENSCAFP00000063394	ENSCAFP00000041707	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Uncharacterized protein.	0.717
CD4	DLA-DOA	ENSCAFP00000063394	ENSCAFP00000001280	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	MHC class II antigen DO alpha; Belongs to the MHC class II family.	0.910
CD4	DLA-DRA	ENSCAFP00000063394	ENSCAFP00000045482	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.984