ROS1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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[Homology]

Score

ROS1

Tyrosine-protein kinase receptor. (2343 aa)

Predicted Functional Partners:

EML4

0.911

GRB2

0.885

PIK3CA

0.783

KRAS

0.777

PTPN6

0.769

PLCG2

0.697

PLCG1

0.697

PIK3R1

0.671

GAB1

0.666

EGFR

0.664

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	EML4	ENSCAFP00000005164	ENSCAFP00000060052	Receptor protein-tyrosine kinase.	EMAP like 4.	0.683
EGFR	GAB1	ENSCAFP00000005164	ENSCAFP00000005384	Receptor protein-tyrosine kinase.	GRB2 associated binding protein 1.	0.996
EGFR	GRB2	ENSCAFP00000005164	ENSCAFP00000049390	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.999
EGFR	KRAS	ENSCAFP00000005164	ENSCAFP00000064230	Receptor protein-tyrosine kinase.	KRAS proto-oncogene, GTPase.	0.993
EGFR	PIK3CA	ENSCAFP00000005164	ENSCAFP00000048355	Receptor protein-tyrosine kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.998
EGFR	PIK3R1	ENSCAFP00000005164	ENSCAFP00000011322	Receptor protein-tyrosine kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.997
EGFR	PLCG1	ENSCAFP00000005164	ENSCAFP00000046841	Receptor protein-tyrosine kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.996
EGFR	PLCG2	ENSCAFP00000005164	ENSCAFP00000029622	Receptor protein-tyrosine kinase.	Phosphoinositide phospholipase C.	0.992
EGFR	PTPN6	ENSCAFP00000005164	ENSCAFP00000043746	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.893
EGFR	ROS1	ENSCAFP00000005164	ENSCAFP00000001313	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.664
EML4	EGFR	ENSCAFP00000060052	ENSCAFP00000005164	EMAP like 4.	Receptor protein-tyrosine kinase.	0.683
EML4	KRAS	ENSCAFP00000060052	ENSCAFP00000064230	EMAP like 4.	KRAS proto-oncogene, GTPase.	0.949
EML4	PIK3CA	ENSCAFP00000060052	ENSCAFP00000048355	EMAP like 4.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.927
EML4	PIK3R1	ENSCAFP00000060052	ENSCAFP00000011322	EMAP like 4.	Phosphoinositide-3-kinase regulatory subunit 1.	0.885
EML4	PLCG1	ENSCAFP00000060052	ENSCAFP00000046841	EMAP like 4.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.881
EML4	PLCG2	ENSCAFP00000060052	ENSCAFP00000029622	EMAP like 4.	Phosphoinositide phospholipase C.	0.881
EML4	ROS1	ENSCAFP00000060052	ENSCAFP00000001313	EMAP like 4.	Tyrosine-protein kinase receptor.	0.911
GAB1	EGFR	ENSCAFP00000005384	ENSCAFP00000005164	GRB2 associated binding protein 1.	Receptor protein-tyrosine kinase.	0.996
GAB1	GRB2	ENSCAFP00000005384	ENSCAFP00000049390	GRB2 associated binding protein 1.	Growth factor receptor bound protein 2.	0.999
GAB1	PIK3CA	ENSCAFP00000005384	ENSCAFP00000048355	GRB2 associated binding protein 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.958