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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMDT1Single-pass membrane protein with aspartate rich tail 1. (107 aa)    
Predicted Functional Partners:
MCU
Mitochondrial calcium uniporter.
    
 0.990
MICU1
Mitochondrial calcium uptake 1.
    
 0.988
MCUB
Mitochondrial calcium uniporter dominant negative beta subunit.
    
 0.967
MICU2
Mitochondrial calcium uptake 2.
    
 0.958
MICU3
Mitochondrial calcium uptake family member 3.
     
 0.832
MAIP1
Matrix AAA peptidase interacting protein 1.
     
 0.769
NDUFA8
NADH:ubiquinone oxidoreductase subunit A8.
   
  
 0.731
EDF1
Endothelial differentiation related factor 1.
   
    0.702
AFG3L2
AFG3 like matrix AAA peptidase subunit 2.
   
 
 0.691
NDUFB7
NADH:ubiquinone oxidoreductase subunit B7.
   
    0.684
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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