TNFRSF13C protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TNFRSF13C

TNF receptor superfamily member 13C. (286 aa)

Predicted Functional Partners:

TNFSF13B

0.982

TRAF3

0.949

TNFSF12

0.845

CD79B

0.780

TRAF2

0.759

MS4A1

0.719

LTBR

0.697

CD40LG

0.690

TRAF5

0.689

TNFSF13

0.677

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD40LG	LTBR	ENSCAFP00000027967	ENSCAFP00000042376	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	Lymphotoxin beta receptor.	0.869
CD40LG	TNFRSF13C	ENSCAFP00000027967	ENSCAFP00000001422	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	TNF receptor superfamily member 13C.	0.690
CD40LG	TNFSF12	ENSCAFP00000027967	ENSCAFP00000052033	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.593
CD40LG	TNFSF13B	ENSCAFP00000027967	ENSCAFP00000035956	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	Tumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family.	0.742
CD40LG	TRAF2	ENSCAFP00000027967	ENSCAFP00000028895	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.612
CD40LG	TRAF3	ENSCAFP00000027967	ENSCAFP00000026713	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.711
CD79B	MS4A1	ENSCAFP00000018654	ENSCAFP00000035044	CD79b molecule.	B-lymphocyte antigen CD20; B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.	0.843
CD79B	TNFRSF13C	ENSCAFP00000018654	ENSCAFP00000001422	CD79b molecule.	TNF receptor superfamily member 13C.	0.780
LTBR	CD40LG	ENSCAFP00000042376	ENSCAFP00000027967	Lymphotoxin beta receptor.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	0.869
LTBR	TNFRSF13C	ENSCAFP00000042376	ENSCAFP00000001422	Lymphotoxin beta receptor.	TNF receptor superfamily member 13C.	0.697
LTBR	TNFSF12	ENSCAFP00000042376	ENSCAFP00000052033	Lymphotoxin beta receptor.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.628
LTBR	TNFSF13B	ENSCAFP00000042376	ENSCAFP00000035956	Lymphotoxin beta receptor.	Tumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family.	0.741
LTBR	TRAF2	ENSCAFP00000042376	ENSCAFP00000028895	Lymphotoxin beta receptor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.957
LTBR	TRAF3	ENSCAFP00000042376	ENSCAFP00000026713	Lymphotoxin beta receptor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.985
LTBR	TRAF5	ENSCAFP00000042376	ENSCAFP00000048548	Lymphotoxin beta receptor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.677
MS4A1	CD79B	ENSCAFP00000035044	ENSCAFP00000018654	B-lymphocyte antigen CD20; B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.	CD79b molecule.	0.843
MS4A1	TNFRSF13C	ENSCAFP00000035044	ENSCAFP00000001422	B-lymphocyte antigen CD20; B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.	TNF receptor superfamily member 13C.	0.719
TNFRSF13C	CD40LG	ENSCAFP00000001422	ENSCAFP00000027967	TNF receptor superfamily member 13C.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	0.690
TNFRSF13C	CD79B	ENSCAFP00000001422	ENSCAFP00000018654	TNF receptor superfamily member 13C.	CD79b molecule.	0.780
TNFRSF13C	LTBR	ENSCAFP00000001422	ENSCAFP00000042376	TNF receptor superfamily member 13C.	Lymphotoxin beta receptor.	0.697