STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MEI1Meiotic double-stranded break formation protein 1. (1272 aa)    
Predicted Functional Partners:
ANKRD31
Ankyrin repeat domain 31.
    
 
 0.916
REC114
REC114 meiotic recombination protein.
      
 0.870
RAE1
SPO11 initiator of meiotic double stranded breaks.
      
 0.793
SYCE1
Synaptonemal complex central element protein 1.
      
 0.764
HORMAD1
HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...]
      
 0.748
M1AP
Meiosis 1 associated protein.
      
 0.747
KATNBL1
Katanin regulatory subunit B1 like 1.
      
 0.688
REC8
REC8 meiotic recombination protein.
      
 0.661
PMPCA
Peptidase, mitochondrial processing alpha subunit; Belongs to the peptidase M16 family.
    
   0.657
PIWIL1
Piwi like RNA-mediated gene silencing 1; Belongs to the argonaute family.
      
 0.628
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (24%) [HD]