PITX1 protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

PITX1

Homeobox protein. (313 aa)

Predicted Functional Partners:

LHX3

0.714

LHX4

0.638

CTNNB1

0.621

TBX4

0.616

PITX3

0.613

FAM161A

0.591

IMPG2

0.532

AR

0.523

FSHB

0.521

MCM6

0.519

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CTNNB1	ENSCAFP00000024499	ENSCAFP00000007783	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.965
AR	PITX1	ENSCAFP00000024499	ENSCAFP00000001499	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Homeobox protein.	0.523
CTNNB1	AR	ENSCAFP00000007783	ENSCAFP00000024499	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	0.965
CTNNB1	PITX1	ENSCAFP00000007783	ENSCAFP00000001499	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Homeobox protein.	0.621
CTNNB1	PITX3	ENSCAFP00000007783	ENSCAFP00000042514	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Homeobox protein.	0.518
FAM161A	IMPG2	ENSCAFP00000004583	ENSCAFP00000014040	FAM161 centrosomal protein A.	Interphotoreceptor matrix proteoglycan 2.	0.888
FAM161A	PITX1	ENSCAFP00000004583	ENSCAFP00000001499	FAM161 centrosomal protein A.	Homeobox protein.	0.591
FSHB	LHX3	ENSCAFP00000015157	ENSCAFP00000018765	Follicle stimulating hormone beta subunit.	LIM homeobox 3.	0.469
FSHB	PITX1	ENSCAFP00000015157	ENSCAFP00000001499	Follicle stimulating hormone beta subunit.	Homeobox protein.	0.521
IMPG2	FAM161A	ENSCAFP00000014040	ENSCAFP00000004583	Interphotoreceptor matrix proteoglycan 2.	FAM161 centrosomal protein A.	0.888
IMPG2	PITX1	ENSCAFP00000014040	ENSCAFP00000001499	Interphotoreceptor matrix proteoglycan 2.	Homeobox protein.	0.532
LHX3	FSHB	ENSCAFP00000018765	ENSCAFP00000015157	LIM homeobox 3.	Follicle stimulating hormone beta subunit.	0.469
LHX3	LHX4	ENSCAFP00000018765	ENSCAFP00000062638	LIM homeobox 3.	LIM homeobox 4.	0.660
LHX3	PITX1	ENSCAFP00000018765	ENSCAFP00000001499	LIM homeobox 3.	Homeobox protein.	0.714
LHX3	PITX3	ENSCAFP00000018765	ENSCAFP00000042514	LIM homeobox 3.	Homeobox protein.	0.431
LHX4	LHX3	ENSCAFP00000062638	ENSCAFP00000018765	LIM homeobox 4.	LIM homeobox 3.	0.660
LHX4	PITX1	ENSCAFP00000062638	ENSCAFP00000001499	LIM homeobox 4.	Homeobox protein.	0.638
MCM6	PITX1	ENSCAFP00000007692	ENSCAFP00000001499	DNA helicase; Belongs to the MCM family.	Homeobox protein.	0.519
PITX1	AR	ENSCAFP00000001499	ENSCAFP00000024499	Homeobox protein.	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	0.523
PITX1	CTNNB1	ENSCAFP00000001499	ENSCAFP00000007783	Homeobox protein.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.621