STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RNF146Ring finger protein 146. (359 aa)    
Predicted Functional Partners:
TNKS
Poly [ADP-ribose] polymerase.
   
 0.982
TNKS2
Poly [ADP-ribose] polymerase.
   
 0.936
UBE2D1
Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.840
AXIN1
Axin 1.
   
 0.817
SH3BP5L
SH3 binding domain protein 5 like.
    
 
 0.801
AXIN2
Axin 2.
    
 0.780
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
   
 
 0.748
C6orf58
Chromosome 6 open reading frame 58.
      
 0.747
PARP2
Poly [ADP-ribose] polymerase.
    
 
 0.745
MMACHC
Metabolism of cobalamin associated C.
   
  
 0.737
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.