TG protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

TG

Thyroglobulin. (2762 aa)

Predicted Functional Partners:

TPO

0.966

LRP2

0.896

ASGR2

0.881

TSHR

0.872

NKX2-2

0.811

PAX8

0.810

FOXE1

0.807

LOC475605

0.792

TSHB

0.788

MB

0.776

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASGR2	TG	ENSCAFP00000054196	ENSCAFP00000001589	Asialoglycoprotein receptor 2.	Thyroglobulin.	0.881
FOXE1	PAX8	ENSCAFP00000048967	ENSCAFP00000010846	Fork-head domain-containing protein.	Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.	0.830
FOXE1	TG	ENSCAFP00000048967	ENSCAFP00000001589	Fork-head domain-containing protein.	Thyroglobulin.	0.807
FOXE1	TPO	ENSCAFP00000048967	ENSCAFP00000004788	Fork-head domain-containing protein.	Thyroid peroxidase; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). Belongs to the peroxidase family. XPO subfamily.	0.674
FOXE1	TSHR	ENSCAFP00000048967	ENSCAFP00000025490	Fork-head domain-containing protein.	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.733
LOC475605	TG	ENSCAFP00000065293	ENSCAFP00000001589	Uncharacterized protein.	Thyroglobulin.	0.792
LRP2	TG	ENSCAFP00000017993	ENSCAFP00000001589	LDL receptor related protein 2.	Thyroglobulin.	0.896
MB	TG	ENSCAFP00000044151	ENSCAFP00000001589	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	Thyroglobulin.	0.776
NKX2-2	PAX8	ENSCAFP00000063267	ENSCAFP00000010846	Thyroid transcription factor 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis; Belongs to the NK-2 homeobox family.	Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.	0.640
NKX2-2	TG	ENSCAFP00000063267	ENSCAFP00000001589	Thyroid transcription factor 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis; Belongs to the NK-2 homeobox family.	Thyroglobulin.	0.811
NKX2-2	TPO	ENSCAFP00000063267	ENSCAFP00000004788	Thyroid transcription factor 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis; Belongs to the NK-2 homeobox family.	Thyroid peroxidase; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). Belongs to the peroxidase family. XPO subfamily.	0.404
PAX8	FOXE1	ENSCAFP00000010846	ENSCAFP00000048967	Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.	Fork-head domain-containing protein.	0.830
PAX8	NKX2-2	ENSCAFP00000010846	ENSCAFP00000063267	Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.	Thyroid transcription factor 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis; Belongs to the NK-2 homeobox family.	0.640
PAX8	TG	ENSCAFP00000010846	ENSCAFP00000001589	Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.	Thyroglobulin.	0.810
PAX8	TPO	ENSCAFP00000010846	ENSCAFP00000004788	Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.	Thyroid peroxidase; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). Belongs to the peroxidase family. XPO subfamily.	0.591
PAX8	TSHB	ENSCAFP00000010846	ENSCAFP00000014272	Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.	Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism.	0.460
PAX8	TSHR	ENSCAFP00000010846	ENSCAFP00000025490	Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.806
TG	ASGR2	ENSCAFP00000001589	ENSCAFP00000054196	Thyroglobulin.	Asialoglycoprotein receptor 2.	0.881
TG	FOXE1	ENSCAFP00000001589	ENSCAFP00000048967	Thyroglobulin.	Fork-head domain-containing protein.	0.807
TG	LOC475605	ENSCAFP00000001589	ENSCAFP00000065293	Thyroglobulin.	Uncharacterized protein.	0.792