LOC102156614 protein (Canis lupus familiaris)

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LOC102156614

Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (333 aa)

Predicted Functional Partners:

TMPRSS2

0.899

FURIN

0.890

CTSB

0.857

CTSD

0.843

MMP7

0.836

CD74

0.830

CTSH

0.821

MMP13

0.817

ACE2

0.817

SERPINB13

0.766

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	CTSB	ENSCAFP00000041771	ENSCAFP00000059573	Angiotensin-converting enzyme.	Cathepsin B; Belongs to the peptidase C1 family.	0.587
ACE2	CTSD	ENSCAFP00000041771	ENSCAFP00000014791	Angiotensin-converting enzyme.	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	0.581
ACE2	FURIN	ENSCAFP00000041771	ENSCAFP00000065874	Angiotensin-converting enzyme.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.902
ACE2	LOC102156614	ENSCAFP00000041771	ENSCAFP00000001630	Angiotensin-converting enzyme.	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	0.817
ACE2	TMPRSS2	ENSCAFP00000041771	ENSCAFP00000041591	Angiotensin-converting enzyme.	Uncharacterized protein.	0.986
CD74	CTSB	ENSCAFP00000045678	ENSCAFP00000059573	CD74 molecule.	Cathepsin B; Belongs to the peptidase C1 family.	0.931
CD74	CTSH	ENSCAFP00000045678	ENSCAFP00000031547	CD74 molecule.	Cathepsin H; Belongs to the peptidase C1 family.	0.421
CD74	LOC102156614	ENSCAFP00000045678	ENSCAFP00000001630	CD74 molecule.	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	0.830
CTSB	ACE2	ENSCAFP00000059573	ENSCAFP00000041771	Cathepsin B; Belongs to the peptidase C1 family.	Angiotensin-converting enzyme.	0.587
CTSB	CD74	ENSCAFP00000059573	ENSCAFP00000045678	Cathepsin B; Belongs to the peptidase C1 family.	CD74 molecule.	0.931
CTSB	CTSD	ENSCAFP00000059573	ENSCAFP00000014791	Cathepsin B; Belongs to the peptidase C1 family.	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	0.975
CTSB	CTSH	ENSCAFP00000059573	ENSCAFP00000031547	Cathepsin B; Belongs to the peptidase C1 family.	Cathepsin H; Belongs to the peptidase C1 family.	0.919
CTSB	FURIN	ENSCAFP00000059573	ENSCAFP00000065874	Cathepsin B; Belongs to the peptidase C1 family.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.760
CTSB	LOC102156614	ENSCAFP00000059573	ENSCAFP00000001630	Cathepsin B; Belongs to the peptidase C1 family.	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	0.857
CTSB	TMPRSS2	ENSCAFP00000059573	ENSCAFP00000041591	Cathepsin B; Belongs to the peptidase C1 family.	Uncharacterized protein.	0.818
CTSD	ACE2	ENSCAFP00000014791	ENSCAFP00000041771	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	Angiotensin-converting enzyme.	0.581
CTSD	CTSB	ENSCAFP00000014791	ENSCAFP00000059573	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	Cathepsin B; Belongs to the peptidase C1 family.	0.975
CTSD	CTSH	ENSCAFP00000014791	ENSCAFP00000031547	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	Cathepsin H; Belongs to the peptidase C1 family.	0.868
CTSD	LOC102156614	ENSCAFP00000014791	ENSCAFP00000001630	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	0.843
CTSD	MMP7	ENSCAFP00000014791	ENSCAFP00000030464	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	Matrix metallopeptidase 7.	0.503

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