IBA57 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IBA57

Iron-sulfur cluster assembly factor IBA57. (346 aa)

Predicted Functional Partners:

ISCA2

0.988

LIAS

0.829

ENSCAFP00000061052

0.817

MTHFD2L

0.805

GLRX5

0.804

GLDC

0.804

MTHFR

0.768

FXN

0.711

ERLIN1

0.676

ZFYVE27

0.670

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCAFP00000061052	FXN	ENSCAFP00000061052	ENSCAFP00000036075	Fe-S_biosyn domain-containing protein.	Frataxin.	0.509
ENSCAFP00000061052	GLRX5	ENSCAFP00000061052	ENSCAFP00000031487	Fe-S_biosyn domain-containing protein.	Glutaredoxin 5.	0.630
ENSCAFP00000061052	IBA57	ENSCAFP00000061052	ENSCAFP00000001666	Fe-S_biosyn domain-containing protein.	Iron-sulfur cluster assembly factor IBA57.	0.817
ENSCAFP00000061052	ISCA2	ENSCAFP00000061052	ENSCAFP00000053418	Fe-S_biosyn domain-containing protein.	Fe-S_biosyn domain-containing protein.	0.933
ENSCAFP00000061052	LIAS	ENSCAFP00000061052	ENSCAFP00000045194	Fe-S_biosyn domain-containing protein.	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.602
ERLIN1	IBA57	ENSCAFP00000014077	ENSCAFP00000001666	ER lipid raft associated 1.	Iron-sulfur cluster assembly factor IBA57.	0.676
ERLIN1	ZFYVE27	ENSCAFP00000014077	ENSCAFP00000043454	ER lipid raft associated 1.	Zinc finger FYVE-type containing 27.	0.669
FXN	ENSCAFP00000061052	ENSCAFP00000036075	ENSCAFP00000061052	Frataxin.	Fe-S_biosyn domain-containing protein.	0.509
FXN	GLRX5	ENSCAFP00000036075	ENSCAFP00000031487	Frataxin.	Glutaredoxin 5.	0.656
FXN	IBA57	ENSCAFP00000036075	ENSCAFP00000001666	Frataxin.	Iron-sulfur cluster assembly factor IBA57.	0.711
FXN	ISCA2	ENSCAFP00000036075	ENSCAFP00000053418	Frataxin.	Fe-S_biosyn domain-containing protein.	0.508
FXN	LIAS	ENSCAFP00000036075	ENSCAFP00000045194	Frataxin.	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.722
GLDC	IBA57	ENSCAFP00000051226	ENSCAFP00000001666	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Iron-sulfur cluster assembly factor IBA57.	0.804
GLDC	LIAS	ENSCAFP00000051226	ENSCAFP00000045194	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.448
GLDC	MTHFD2L	ENSCAFP00000051226	ENSCAFP00000059857	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.927
GLDC	MTHFR	ENSCAFP00000051226	ENSCAFP00000060565	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.941
GLRX5	ENSCAFP00000061052	ENSCAFP00000031487	ENSCAFP00000061052	Glutaredoxin 5.	Fe-S_biosyn domain-containing protein.	0.630
GLRX5	FXN	ENSCAFP00000031487	ENSCAFP00000036075	Glutaredoxin 5.	Frataxin.	0.656
GLRX5	IBA57	ENSCAFP00000031487	ENSCAFP00000001666	Glutaredoxin 5.	Iron-sulfur cluster assembly factor IBA57.	0.804
GLRX5	ISCA2	ENSCAFP00000031487	ENSCAFP00000053418	Glutaredoxin 5.	Fe-S_biosyn domain-containing protein.	0.961