STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HMGA1High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity); Belongs to the HMGA family. (106 aa)    
Predicted Functional Partners:
PACSIN1
Protein kinase C and casein kinase substrate in neurons 1.
      
 0.737
MYBL1
MYB proto-oncogene like 1.
   
  
 0.720
SPDEF
SAM pointed domain containing ETS transcription factor.
      
 0.651
SCUBE3
Signal peptide, CUB domain and EGF like domain containing 3.
      
 0.620
BANF2
Barrier to autointegration factor 2.
    
 
 0.605
TAF11
TATA-box binding protein associated factor 11.
   
  
 0.563
IGF2BP1
Insulin like growth factor 2 mRNA binding protein 1.
   
 
 0.529
ARID3B
AT-rich interaction domain 3B.
      
 0.522
RGR
Retinal G protein coupled receptor; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
      
 0.519
IGF2BP2
Insulin like growth factor 2 mRNA binding protein 2.
   
 
 0.516
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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