STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDC25CCell division cycle 25C. (476 aa)    
Predicted Functional Partners:
PLK1
Serine/threonine-protein kinase PLK.
   
 0.979
CHEK1
Checkpoint kinase 1.
   
 0.975
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.960
CCNB1
Uncharacterized protein; Belongs to the cyclin family.
   
 0.945
PLK3
Serine/threonine-protein kinase PLK.
   
 0.938
PKN1
Protein kinase N1.
    
 0.909
CCNE1
Cyclin E1; Belongs to the cyclin family.
   
 0.901
CCNE2
Cyclin E2; Belongs to the cyclin family.
   
 0.882
CCNA2
Cyclin A2; Belongs to the cyclin family.
   
 0.867
YWHAZ-2
14_3_3 domain-containing protein; Belongs to the 14-3-3 family.
    
 0.855
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.