STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)    
Predicted Functional Partners:
UNC119
Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Proba [...]
    
   0.795
FOXA3
Forkhead box A3.
   
  
 0.785
PACSIN1
Protein kinase C and casein kinase substrate in neurons 1.
      
 0.750
PRDM16
PR/SET domain 16.
    
   0.669
AGR2
Anterior gradient 2, protein disulphide isomerase family member.
   
 
 0.657
MAPKAPK3
MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.
     
 0.627
DIXDC1
DIX domain containing 1.
      
 0.598
CLCA1
Chloride channel accessory 1.
      
 0.595
SCUBE3
Signal peptide, CUB domain and EGF like domain containing 3.
      
 0.592
BGN
Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
     
 0.581
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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