SPDEF protein (Canis lupus familiaris) - STRING interaction network

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Score

SPDEF

SAM pointed domain containing ETS transcription factor. (335 aa)

Predicted Functional Partners:

PACSIN1

0.792

FOXA3

0.758

HMGA1

0.651

AGR2

0.608

ATOH1

0.608

IL13

0.584

DIXDC1

0.573

SCUBE3

0.562

STAT6

0.545

TAF11

0.526

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGR2	FOXA3	ENSCAFP00000003553	ENSCAFP00000006480	Anterior gradient 2, protein disulphide isomerase family member.	Forkhead box A3.	0.429
AGR2	SPDEF	ENSCAFP00000003553	ENSCAFP00000001756	Anterior gradient 2, protein disulphide isomerase family member.	SAM pointed domain containing ETS transcription factor.	0.608
ATOH1	SPDEF	ENSCAFP00000014743	ENSCAFP00000001756	Atonal bHLH transcription factor 1.	SAM pointed domain containing ETS transcription factor.	0.608
DIXDC1	SPDEF	ENSCAFP00000020742	ENSCAFP00000001756	DIX domain containing 1.	SAM pointed domain containing ETS transcription factor.	0.573
FOXA3	AGR2	ENSCAFP00000006480	ENSCAFP00000003553	Forkhead box A3.	Anterior gradient 2, protein disulphide isomerase family member.	0.429
FOXA3	SPDEF	ENSCAFP00000006480	ENSCAFP00000001756	Forkhead box A3.	SAM pointed domain containing ETS transcription factor.	0.758
HMGA1	PACSIN1	ENSCAFP00000001724	ENSCAFP00000052171	High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity); Belongs to the HMGA family.	Protein kinase C and casein kinase substrate in neurons 1.	0.737
HMGA1	SCUBE3	ENSCAFP00000001724	ENSCAFP00000038328	High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity); Belongs to the HMGA family.	Signal peptide, CUB domain and EGF like domain containing 3.	0.620
HMGA1	SPDEF	ENSCAFP00000001724	ENSCAFP00000001756	High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity); Belongs to the HMGA family.	SAM pointed domain containing ETS transcription factor.	0.651
HMGA1	TAF11	ENSCAFP00000001724	ENSCAFP00000001780	High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity); Belongs to the HMGA family.	TATA-box binding protein associated factor 11.	0.563
IL13	SPDEF	ENSCAFP00000001250	ENSCAFP00000001756	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	SAM pointed domain containing ETS transcription factor.	0.584
IL13	STAT6	ENSCAFP00000001250	ENSCAFP00000046565	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	Signal transducer and activator of transcription.	0.945
PACSIN1	HMGA1	ENSCAFP00000052171	ENSCAFP00000001724	Protein kinase C and casein kinase substrate in neurons 1.	High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity); Belongs to the HMGA family.	0.737
PACSIN1	SCUBE3	ENSCAFP00000052171	ENSCAFP00000038328	Protein kinase C and casein kinase substrate in neurons 1.	Signal peptide, CUB domain and EGF like domain containing 3.	0.806
PACSIN1	SPDEF	ENSCAFP00000052171	ENSCAFP00000001756	Protein kinase C and casein kinase substrate in neurons 1.	SAM pointed domain containing ETS transcription factor.	0.792
PACSIN1	TAF11	ENSCAFP00000052171	ENSCAFP00000001780	Protein kinase C and casein kinase substrate in neurons 1.	TATA-box binding protein associated factor 11.	0.522
SCUBE3	HMGA1	ENSCAFP00000038328	ENSCAFP00000001724	Signal peptide, CUB domain and EGF like domain containing 3.	High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity); Belongs to the HMGA family.	0.620
SCUBE3	PACSIN1	ENSCAFP00000038328	ENSCAFP00000052171	Signal peptide, CUB domain and EGF like domain containing 3.	Protein kinase C and casein kinase substrate in neurons 1.	0.806
SCUBE3	SPDEF	ENSCAFP00000038328	ENSCAFP00000001756	Signal peptide, CUB domain and EGF like domain containing 3.	SAM pointed domain containing ETS transcription factor.	0.562
SCUBE3	TAF11	ENSCAFP00000038328	ENSCAFP00000001780	Signal peptide, CUB domain and EGF like domain containing 3.	TATA-box binding protein associated factor 11.	0.792