| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGEF12 | CDC42-2 | ENSCAFP00000017590 | ENSCAFP00000060180 | Rho guanine nucleotide exchange factor 12. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.663 |
| ARHGEF12 | DEF6 | ENSCAFP00000017590 | ENSCAFP00000001876 | Rho guanine nucleotide exchange factor 12. | DEF6 guanine nucleotide exchange factor. | 0.430 |
| ARHGEF12 | GNA13 | ENSCAFP00000017590 | ENSCAFP00000016361 | Rho guanine nucleotide exchange factor 12. | G protein subunit alpha 13. | 0.997 |
| ARHGEF12 | LOC100856635 | ENSCAFP00000017590 | ENSCAFP00000014017 | Rho guanine nucleotide exchange factor 12. | Uncharacterized protein. | 0.461 |
| ARHGEF12 | MCF2L | ENSCAFP00000017590 | ENSCAFP00000050864 | Rho guanine nucleotide exchange factor 12. | MCF.2 cell line derived transforming sequence like. | 0.447 |
| ARHGEF12 | PLEKHG2 | ENSCAFP00000017590 | ENSCAFP00000038098 | Rho guanine nucleotide exchange factor 12. | Pleckstrin homology and RhoGEF domain containing G2. | 0.457 |
| ARHGEF12 | PLEKHG3 | ENSCAFP00000017590 | ENSCAFP00000046821 | Rho guanine nucleotide exchange factor 12. | Pleckstrin homology and RhoGEF domain containing G3. | 0.447 |
| ARHGEF12 | RAC1 | ENSCAFP00000017590 | ENSCAFP00000032062 | Rho guanine nucleotide exchange factor 12. | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | 0.552 |
| ARHGEF12 | RASGRF2 | ENSCAFP00000017590 | ENSCAFP00000038456 | Rho guanine nucleotide exchange factor 12. | Ras protein specific guanine nucleotide releasing factor 2. | 0.464 |
| CDC42-2 | ARHGEF12 | ENSCAFP00000060180 | ENSCAFP00000017590 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Rho guanine nucleotide exchange factor 12. | 0.663 |
| CDC42-2 | DEF6 | ENSCAFP00000060180 | ENSCAFP00000001876 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | DEF6 guanine nucleotide exchange factor. | 0.455 |
| CDC42-2 | GNA13 | ENSCAFP00000060180 | ENSCAFP00000016361 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | G protein subunit alpha 13. | 0.533 |
| CDC42-2 | LOC100856635 | ENSCAFP00000060180 | ENSCAFP00000014017 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Uncharacterized protein. | 0.842 |
| CDC42-2 | MCF2L | ENSCAFP00000060180 | ENSCAFP00000050864 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | MCF.2 cell line derived transforming sequence like. | 0.825 |
| CDC42-2 | PLEKHG2 | ENSCAFP00000060180 | ENSCAFP00000038098 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Pleckstrin homology and RhoGEF domain containing G2. | 0.557 |
| CDC42-2 | PLEKHG3 | ENSCAFP00000060180 | ENSCAFP00000046821 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Pleckstrin homology and RhoGEF domain containing G3. | 0.448 |
| CDC42-2 | RAC1 | ENSCAFP00000060180 | ENSCAFP00000032062 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | 0.944 |
| CDC42-2 | RAC2 | ENSCAFP00000060180 | ENSCAFP00000002174 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Rac family small GTPase 2. | 0.851 |
| CDC42-2 | RASGRF2 | ENSCAFP00000060180 | ENSCAFP00000038456 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Ras protein specific guanine nucleotide releasing factor 2. | 0.530 |
| DEF6 | ARHGEF12 | ENSCAFP00000001876 | ENSCAFP00000017590 | DEF6 guanine nucleotide exchange factor. | Rho guanine nucleotide exchange factor 12. | 0.430 |
