CTSL3 protein (Canis lupus familiaris) - STRING interaction network

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Score

CTSL3

Uncharacterized protein; Belongs to the peptidase C1 family. (341 aa)

Predicted Functional Partners:

LGMN

0.922

TMPRSS2

0.897

CTSD

0.895

FURIN

0.883

CD74

0.821

ACE2

0.818

BCL2

0.798

BCL2L1

0.796

HPSE

0.760

TLR9-2

0.760

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	CTSD	ENSCAFP00000041771	ENSCAFP00000014791	Angiotensin-converting enzyme.	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	0.581
ACE2	CTSL3	ENSCAFP00000041771	ENSCAFP00000001877	Angiotensin-converting enzyme.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.818
ACE2	FURIN	ENSCAFP00000041771	ENSCAFP00000065874	Angiotensin-converting enzyme.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.902
ACE2	TMPRSS2	ENSCAFP00000041771	ENSCAFP00000041591	Angiotensin-converting enzyme.	Uncharacterized protein.	0.986
BCL2	BCL2L1	ENSCAFP00000000102	ENSCAFP00000010478	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	BCL2 like 1.	0.995
BCL2	CTSD	ENSCAFP00000000102	ENSCAFP00000014791	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	0.910
BCL2	CTSL3	ENSCAFP00000000102	ENSCAFP00000001877	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	Uncharacterized protein; Belongs to the peptidase C1 family.	0.798
BCL2L1	BCL2	ENSCAFP00000010478	ENSCAFP00000000102	BCL2 like 1.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	0.995
BCL2L1	CTSD	ENSCAFP00000010478	ENSCAFP00000014791	BCL2 like 1.	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	0.882
BCL2L1	CTSL3	ENSCAFP00000010478	ENSCAFP00000001877	BCL2 like 1.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.796
CD74	CTSL3	ENSCAFP00000045678	ENSCAFP00000001877	CD74 molecule.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.821
CD74	LGMN	ENSCAFP00000045678	ENSCAFP00000016239	CD74 molecule.	Legumain.	0.900
CTSD	ACE2	ENSCAFP00000014791	ENSCAFP00000041771	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	Angiotensin-converting enzyme.	0.581
CTSD	BCL2	ENSCAFP00000014791	ENSCAFP00000000102	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	0.910
CTSD	BCL2L1	ENSCAFP00000014791	ENSCAFP00000010478	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	BCL2 like 1.	0.882
CTSD	CTSL3	ENSCAFP00000014791	ENSCAFP00000001877	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.895
CTSD	LGMN	ENSCAFP00000014791	ENSCAFP00000016239	Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.	Legumain.	0.618
CTSL3	ACE2	ENSCAFP00000001877	ENSCAFP00000041771	Uncharacterized protein; Belongs to the peptidase C1 family.	Angiotensin-converting enzyme.	0.818
CTSL3	BCL2	ENSCAFP00000001877	ENSCAFP00000000102	Uncharacterized protein; Belongs to the peptidase C1 family.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	0.798
CTSL3	BCL2L1	ENSCAFP00000001877	ENSCAFP00000010478	Uncharacterized protein; Belongs to the peptidase C1 family.	BCL2 like 1.	0.796