TOMM22 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

TOMM22

Uncharacterized protein. (142 aa)

Predicted Functional Partners:

TOMM7

0.981

TOMM70

0.970

TOMM40

0.968

TOMM5

0.964

TOMM20

0.949

TOMM6

0.941

SAMM50

0.830

TIMM50

0.806

ENSCAFP00000058734

0.715

ENSCAFP00000063916

0.715

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCAFP00000058734	ENSCAFP00000063916	ENSCAFP00000058734	ENSCAFP00000063916	Uncharacterized protein.	Uncharacterized protein.	0.538
ENSCAFP00000058734	TOMM22	ENSCAFP00000058734	ENSCAFP00000001971	Uncharacterized protein.	Uncharacterized protein.	0.715
ENSCAFP00000058734	TOMM40	ENSCAFP00000058734	ENSCAFP00000006902	Uncharacterized protein.	Translocase of outer mitochondrial membrane 40.	0.682
ENSCAFP00000058734	TOMM5	ENSCAFP00000058734	ENSCAFP00000037744	Uncharacterized protein.	Uncharacterized protein.	0.847
ENSCAFP00000058734	TOMM7	ENSCAFP00000058734	ENSCAFP00000037774	Uncharacterized protein.	Translocase of outer mitochondrial membrane 7.	0.790
ENSCAFP00000058734	TOMM70	ENSCAFP00000058734	ENSCAFP00000013696	Uncharacterized protein.	Translocase of outer mitochondrial membrane 70.	0.515
ENSCAFP00000063916	ENSCAFP00000058734	ENSCAFP00000063916	ENSCAFP00000058734	Uncharacterized protein.	Uncharacterized protein.	0.538
ENSCAFP00000063916	TOMM22	ENSCAFP00000063916	ENSCAFP00000001971	Uncharacterized protein.	Uncharacterized protein.	0.715
ENSCAFP00000063916	TOMM40	ENSCAFP00000063916	ENSCAFP00000006902	Uncharacterized protein.	Translocase of outer mitochondrial membrane 40.	0.682
ENSCAFP00000063916	TOMM5	ENSCAFP00000063916	ENSCAFP00000037744	Uncharacterized protein.	Uncharacterized protein.	0.849
ENSCAFP00000063916	TOMM7	ENSCAFP00000063916	ENSCAFP00000037774	Uncharacterized protein.	Translocase of outer mitochondrial membrane 7.	0.790
ENSCAFP00000063916	TOMM70	ENSCAFP00000063916	ENSCAFP00000013696	Uncharacterized protein.	Translocase of outer mitochondrial membrane 70.	0.515
SAMM50	TIMM50	ENSCAFP00000001270	ENSCAFP00000033349	SAMM50 sorting and assembly machinery component.	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.471
SAMM50	TOMM20	ENSCAFP00000001270	ENSCAFP00000016929	SAMM50 sorting and assembly machinery component.	Translocase of outer mitochondrial membrane 20.	0.430
SAMM50	TOMM22	ENSCAFP00000001270	ENSCAFP00000001971	SAMM50 sorting and assembly machinery component.	Uncharacterized protein.	0.830
SAMM50	TOMM40	ENSCAFP00000001270	ENSCAFP00000006902	SAMM50 sorting and assembly machinery component.	Translocase of outer mitochondrial membrane 40.	0.905
SAMM50	TOMM7	ENSCAFP00000001270	ENSCAFP00000037774	SAMM50 sorting and assembly machinery component.	Translocase of outer mitochondrial membrane 7.	0.530
SAMM50	TOMM70	ENSCAFP00000001270	ENSCAFP00000013696	SAMM50 sorting and assembly machinery component.	Translocase of outer mitochondrial membrane 70.	0.557
TIMM50	SAMM50	ENSCAFP00000033349	ENSCAFP00000001270	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	SAMM50 sorting and assembly machinery component.	0.471
TIMM50	TOMM20	ENSCAFP00000033349	ENSCAFP00000016929	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	Translocase of outer mitochondrial membrane 20.	0.410

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.841

expected number of edges:

16

PPI enrichment p-value:

3.86e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

8 of 82

1.26

1.64

5.36e-07

GO:0007165

Signal transduction

9 of 122

1.14

1.4

5.36e-07

GO:0019538

Protein metabolic process

8 of 194

0.88

0.84

5.34e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

7 of 39

1.52

2.26

1.94e-07

GO:0000155

Phosphorelay sensor kinase activity

6 of 35

1.5

2.0

2.21e-06

GO:0140096

Catalytic activity, acting on a protein

9 of 109

1.19

1.54

1.80e-07

GO:0016740

Transferase activity

8 of 304

0.69

0.54

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2313

Phosphorelay signal transduction system, and GGDEF domain

6 of 72

1.19

1.17

0.00018

CL:2397

PAC motif, and Putative diguanylate phosphodiesterase

3 of 12

1.67

1.17

0.0034

CL:2309

Signal transduction, and Flagellar assembly

8 of 171

0.94

0.87

0.00018

CL:2400

Mixed, incl. PAS domain, and SsuA/THI5-like

2 of 6

1.79

0.78

0.0310

CL:2317

Phosphorelay signal transduction system

3 of 29

1.28

0.7

0.0250

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

5 of 58

1.2

0.98

0.0019

KW-0597

Phosphoprotein

5 of 63

1.17

0.95

0.0019

KW-0175

Coiled coil

7 of 254

0.71

0.51

0.0070

KW-0808

Transferase

6 of 237

0.67

0.4

0.0359

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 29

1.65

2.73

2.51e-08

IPR003594

Histidine kinase/HSP90-like ATPase

8 of 40

1.57

2.65

6.63e-09

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

8 of 41

1.56

2.62

6.63e-09

IPR005467

Histidine kinase domain

7 of 37

1.55

2.38

8.52e-08

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

6 of 35

1.5

1.96

3.24e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

8 of 39

1.58

2.89

4.69e-10

SM00388

His Kinase A (phosphoacceptor) domain

5 of 35

1.42

1.61

3.40e-05

SM00448

cheY-homologous receiver domain

5 of 55

1.23

1.21

0.00018

SM00091

PAS domain

3 of 21

1.42

1.03

0.0040

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 21

1.42

1.03

0.0040

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