CBY1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

CBY1

Chibby family member 1, beta catenin antagonist. (127 aa)

Predicted Functional Partners:

YWHAZ-2

0.911

XPO1

0.806

CBY3

0.794

MFSD4A

0.531

CTNNB1

0.444

JUP

0.444

SCNN1D

0.432

SCNN1A

0.432

UCK1

0.423

UCK2

0.423

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBY1	CBY3	ENSCAFP00000001974	ENSCAFP00000000495	Chibby family member 1, beta catenin antagonist.	Chibby family member 3.	0.794
CBY1	CTNNB1	ENSCAFP00000001974	ENSCAFP00000007783	Chibby family member 1, beta catenin antagonist.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.444
CBY1	JUP	ENSCAFP00000001974	ENSCAFP00000023403	Chibby family member 1, beta catenin antagonist.	Uncharacterized protein.	0.444
CBY1	MFSD4A	ENSCAFP00000001974	ENSCAFP00000014887	Chibby family member 1, beta catenin antagonist.	Major facilitator superfamily domain containing 4A.	0.531
CBY1	SCNN1A	ENSCAFP00000001974	ENSCAFP00000043026	Chibby family member 1, beta catenin antagonist.	Sodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.432
CBY1	SCNN1D	ENSCAFP00000001974	ENSCAFP00000028510	Chibby family member 1, beta catenin antagonist.	Sodium channel epithelial 1 delta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.432
CBY1	UCK1	ENSCAFP00000001974	ENSCAFP00000045401	Chibby family member 1, beta catenin antagonist.	Uridine-cytidine kinase 1.	0.423
CBY1	UCK2	ENSCAFP00000001974	ENSCAFP00000062318	Chibby family member 1, beta catenin antagonist.	Uridine-cytidine kinase 2.	0.423
CBY1	XPO1	ENSCAFP00000001974	ENSCAFP00000004579	Chibby family member 1, beta catenin antagonist.	Exportin 1.	0.806
CBY1	YWHAZ-2	ENSCAFP00000001974	ENSCAFP00000042684	Chibby family member 1, beta catenin antagonist.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.911
CBY3	CBY1	ENSCAFP00000000495	ENSCAFP00000001974	Chibby family member 3.	Chibby family member 1, beta catenin antagonist.	0.794
CTNNB1	CBY1	ENSCAFP00000007783	ENSCAFP00000001974	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Chibby family member 1, beta catenin antagonist.	0.444
CTNNB1	JUP	ENSCAFP00000007783	ENSCAFP00000023403	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Uncharacterized protein.	0.997
CTNNB1	YWHAZ-2	ENSCAFP00000007783	ENSCAFP00000042684	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.575
JUP	CBY1	ENSCAFP00000023403	ENSCAFP00000001974	Uncharacterized protein.	Chibby family member 1, beta catenin antagonist.	0.444
JUP	CTNNB1	ENSCAFP00000023403	ENSCAFP00000007783	Uncharacterized protein.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.997
MFSD4A	CBY1	ENSCAFP00000014887	ENSCAFP00000001974	Major facilitator superfamily domain containing 4A.	Chibby family member 1, beta catenin antagonist.	0.531
MFSD4A	SCNN1A	ENSCAFP00000014887	ENSCAFP00000043026	Major facilitator superfamily domain containing 4A.	Sodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.432
MFSD4A	SCNN1D	ENSCAFP00000014887	ENSCAFP00000028510	Major facilitator superfamily domain containing 4A.	Sodium channel epithelial 1 delta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.432
SCNN1A	CBY1	ENSCAFP00000043026	ENSCAFP00000001974	Sodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	Chibby family member 1, beta catenin antagonist.	0.432