STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KCNJ4Potassium voltage-gated channel subfamily J member 4. (448 aa)    
Predicted Functional Partners:
KCNQ3
Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family.
   
 
 0.917
KCNQ1
Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family.
   
 
 0.909
KCNQ2
Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family.
   
 
 0.904
KCNQ4
Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family.
   
 
 0.896
KCNQ5
Potassium voltage-gated channel subfamily Q member 5.
   
 
 0.896
KCNJ2
Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Blocked b [...]
     
 0.886
KCNJ12
Inward rectifier potassium channel.
     
 0.886
KCNJ14
Potassium voltage-gated channel subfamily J member 14.
     
  0.881
DLG4
Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.
   
 
 0.817
GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
     
 0.772
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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