STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SOX10SRY-box transcription factor 10. (468 aa)    
Predicted Functional Partners:
PAX3
Paired box 3.
   
 
 0.931
PLP1
Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
   
  
 0.863
MBP
Myelin basic protein.
   
  
 0.843
OLIG2
Oligodendrocyte transcription factor 2.
   
 
 0.838
GFAP
Glial fibrillary acidic protein; Belongs to the intermediate filament family.
   
 
 0.818
DCT
Uncharacterized protein.
   
 
 0.789
EDN3
Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.
      
 0.757
ASCL1
Achaete-scute family bHLH transcription factor 1.
    
 
 0.741
EDNRB
Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.
   
  
 0.732
OLIG1
Oligodendrocyte transcription factor 1.
   
 
 0.729
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.