TMPRSS6 protein (Canis lupus familiaris) - STRING interaction network

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Score

TMPRSS6

Transmembrane serine protease 6; Belongs to the peptidase S1 family. (802 aa)

Predicted Functional Partners:

HJV

0.965

HAMP

0.853

DCN

0.784

HFE

0.746

TFR2

0.717

SLC25A28

0.599

BMP6

0.584

TFRC

0.580

ANGPTL3

0.546

SLC11A2

0.539

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPTL3	TMPRSS6	ENSCAFP00000027734	ENSCAFP00000002181	Angiopoietin like 3.	Transmembrane serine protease 6; Belongs to the peptidase S1 family.	0.546
BMP6	HAMP	ENSCAFP00000038289	ENSCAFP00000010474	Bone morphogenetic protein 6.	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	0.713
BMP6	HFE	ENSCAFP00000038289	ENSCAFP00000045809	Bone morphogenetic protein 6.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.612
BMP6	HJV	ENSCAFP00000038289	ENSCAFP00000016789	Bone morphogenetic protein 6.	Hemojuvelin BMP co-receptor.	0.798
BMP6	TFR2	ENSCAFP00000038289	ENSCAFP00000021123	Bone morphogenetic protein 6.	Transferrin receptor 2.	0.583
BMP6	TFRC	ENSCAFP00000038289	ENSCAFP00000019067	Bone morphogenetic protein 6.	Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity); Belongs to the [...]	0.411
BMP6	TMPRSS6	ENSCAFP00000038289	ENSCAFP00000002181	Bone morphogenetic protein 6.	Transmembrane serine protease 6; Belongs to the peptidase S1 family.	0.584
DCN	TMPRSS6	ENSCAFP00000009230	ENSCAFP00000002181	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Transmembrane serine protease 6; Belongs to the peptidase S1 family.	0.784
HAMP	BMP6	ENSCAFP00000010474	ENSCAFP00000038289	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	Bone morphogenetic protein 6.	0.713
HAMP	HFE	ENSCAFP00000010474	ENSCAFP00000045809	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.888
HAMP	HJV	ENSCAFP00000010474	ENSCAFP00000016789	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	Hemojuvelin BMP co-receptor.	0.928
HAMP	SLC11A2	ENSCAFP00000010474	ENSCAFP00000011707	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	Solute carrier family 11 member 2.	0.755
HAMP	TFR2	ENSCAFP00000010474	ENSCAFP00000021123	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	Transferrin receptor 2.	0.890
HAMP	TFRC	ENSCAFP00000010474	ENSCAFP00000019067	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity); Belongs to the [...]	0.848
HAMP	TMPRSS6	ENSCAFP00000010474	ENSCAFP00000002181	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	Transmembrane serine protease 6; Belongs to the peptidase S1 family.	0.853
HFE	BMP6	ENSCAFP00000045809	ENSCAFP00000038289	Homeostatic iron regulator; Belongs to the MHC class I family.	Bone morphogenetic protein 6.	0.612
HFE	HAMP	ENSCAFP00000045809	ENSCAFP00000010474	Homeostatic iron regulator; Belongs to the MHC class I family.	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	0.888
HFE	HJV	ENSCAFP00000045809	ENSCAFP00000016789	Homeostatic iron regulator; Belongs to the MHC class I family.	Hemojuvelin BMP co-receptor.	0.989
HFE	SLC11A2	ENSCAFP00000045809	ENSCAFP00000011707	Homeostatic iron regulator; Belongs to the MHC class I family.	Solute carrier family 11 member 2.	0.602
HFE	TFR2	ENSCAFP00000045809	ENSCAFP00000021123	Homeostatic iron regulator; Belongs to the MHC class I family.	Transferrin receptor 2.	0.997