TMPRSS6 protein (Canis lupus familiaris) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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Score

TMPRSS6

Transmembrane serine protease 6; Belongs to the peptidase S1 family. (802 aa)

Predicted Functional Partners:

HJV

0.867

DCN

0.767

TFR2

0.747

HAMP

0.740

HFE

0.688

BMP6

0.615

J9PBG3_CANLF

0.590

ANGPTL3

0.577

CD109

0.569

INSYN2A

0.563

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPTL3	TMPRSS6	ENSCAFP00000027734	ENSCAFP00000002181	Angiopoietin like 3.	Transmembrane serine protease 6; Belongs to the peptidase S1 family.	0.577
BMP6	HAMP	ENSCAFP00000038289	ENSCAFP00000010474	Bone morphogenetic protein 6.	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	0.663
BMP6	HFE	ENSCAFP00000038289	ENSCAFP00000045809	Bone morphogenetic protein 6.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.675
BMP6	HJV	ENSCAFP00000038289	ENSCAFP00000016789	Bone morphogenetic protein 6.	Hemojuvelin BMP co-receptor.	0.818
BMP6	TFR2	ENSCAFP00000038289	ENSCAFP00000021123	Bone morphogenetic protein 6.	Transferrin receptor 2.	0.691
BMP6	TMPRSS6	ENSCAFP00000038289	ENSCAFP00000002181	Bone morphogenetic protein 6.	Transmembrane serine protease 6; Belongs to the peptidase S1 family.	0.615
CD109	J9PBG3_CANLF	ENSCAFP00000063204	ENSCAFP00000043142	CD109 molecule.	IGv domain-containing protein.	0.416
CD109	TMPRSS6	ENSCAFP00000063204	ENSCAFP00000002181	CD109 molecule.	Transmembrane serine protease 6; Belongs to the peptidase S1 family.	0.569
DCN	TMPRSS6	ENSCAFP00000009230	ENSCAFP00000002181	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Transmembrane serine protease 6; Belongs to the peptidase S1 family.	0.767
HAMP	BMP6	ENSCAFP00000010474	ENSCAFP00000038289	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	Bone morphogenetic protein 6.	0.663
HAMP	HFE	ENSCAFP00000010474	ENSCAFP00000045809	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.907
HAMP	HJV	ENSCAFP00000010474	ENSCAFP00000016789	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	Hemojuvelin BMP co-receptor.	0.866
HAMP	TFR2	ENSCAFP00000010474	ENSCAFP00000021123	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	Transferrin receptor 2.	0.911
HAMP	TMPRSS6	ENSCAFP00000010474	ENSCAFP00000002181	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	Transmembrane serine protease 6; Belongs to the peptidase S1 family.	0.740
HFE	BMP6	ENSCAFP00000045809	ENSCAFP00000038289	Homeostatic iron regulator; Belongs to the MHC class I family.	Bone morphogenetic protein 6.	0.675
HFE	HAMP	ENSCAFP00000045809	ENSCAFP00000010474	Homeostatic iron regulator; Belongs to the MHC class I family.	Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family.	0.907
HFE	HJV	ENSCAFP00000045809	ENSCAFP00000016789	Homeostatic iron regulator; Belongs to the MHC class I family.	Hemojuvelin BMP co-receptor.	0.891
HFE	TFR2	ENSCAFP00000045809	ENSCAFP00000021123	Homeostatic iron regulator; Belongs to the MHC class I family.	Transferrin receptor 2.	0.969
HFE	TMPRSS6	ENSCAFP00000045809	ENSCAFP00000002181	Homeostatic iron regulator; Belongs to the MHC class I family.	Transmembrane serine protease 6; Belongs to the peptidase S1 family.	0.688
HJV	BMP6	ENSCAFP00000016789	ENSCAFP00000038289	Hemojuvelin BMP co-receptor.	Bone morphogenetic protein 6.	0.818