WDR97 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

WDR97

WD_REPEATS_REGION domain-containing protein. (1467 aa)

Predicted Functional Partners:

RETSAT

0.730

PYROXD2

0.730

HSD17B7

0.614

DLD

0.568

TXNRD3

0.568

GSR

0.568

TXNRD2

0.568

TXNRD1

0.568

NADK

0.560

ENSCAFP00000060389

0.559

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLD	NADK	ENSCAFP00000005721	ENSCAFP00000028345	Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...]	NAD kinase.	0.552
DLD	WDR97	ENSCAFP00000005721	ENSCAFP00000002224	Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...]	WD_REPEATS_REGION domain-containing protein.	0.568
ENSCAFP00000060389	HSD17B7	ENSCAFP00000060389	ENSCAFP00000065581	Nudix hydrolase domain-containing protein.	Hydroxysteroid 17-beta dehydrogenase 7.	0.620
ENSCAFP00000060389	WDR97	ENSCAFP00000060389	ENSCAFP00000002224	Nudix hydrolase domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.559
GSR	NADK	ENSCAFP00000009702	ENSCAFP00000028345	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	NAD kinase.	0.565
GSR	WDR97	ENSCAFP00000009702	ENSCAFP00000002224	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	WD_REPEATS_REGION domain-containing protein.	0.568
HSD17B7	ENSCAFP00000060389	ENSCAFP00000065581	ENSCAFP00000060389	Hydroxysteroid 17-beta dehydrogenase 7.	Nudix hydrolase domain-containing protein.	0.620
HSD17B7	WDR97	ENSCAFP00000065581	ENSCAFP00000002224	Hydroxysteroid 17-beta dehydrogenase 7.	WD_REPEATS_REGION domain-containing protein.	0.614
NADK	DLD	ENSCAFP00000028345	ENSCAFP00000005721	NAD kinase.	Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...]	0.552
NADK	GSR	ENSCAFP00000028345	ENSCAFP00000009702	NAD kinase.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.565
NADK	TXNRD1	ENSCAFP00000028345	ENSCAFP00000065153	NAD kinase.	Thioredoxin reductase 1; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.543
NADK	TXNRD2	ENSCAFP00000028345	ENSCAFP00000021267	NAD kinase.	Thioredoxin reductase 2.	0.543
NADK	TXNRD3	ENSCAFP00000028345	ENSCAFP00000005807	NAD kinase.	Thioredoxin reductase 3.	0.543
NADK	WDR97	ENSCAFP00000028345	ENSCAFP00000002224	NAD kinase.	WD_REPEATS_REGION domain-containing protein.	0.560
PYROXD2	WDR97	ENSCAFP00000013778	ENSCAFP00000002224	Pyridine nucleotide-disulphide oxidoreductase domain 2.	WD_REPEATS_REGION domain-containing protein.	0.730
RETSAT	WDR97	ENSCAFP00000011561	ENSCAFP00000002224	Retinol saturase.	WD_REPEATS_REGION domain-containing protein.	0.730
TXNRD1	NADK	ENSCAFP00000065153	ENSCAFP00000028345	Thioredoxin reductase 1; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	NAD kinase.	0.543
TXNRD1	TXNRD2	ENSCAFP00000065153	ENSCAFP00000021267	Thioredoxin reductase 1; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Thioredoxin reductase 2.	0.885
TXNRD1	TXNRD3	ENSCAFP00000065153	ENSCAFP00000005807	Thioredoxin reductase 1; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Thioredoxin reductase 3.	0.881
TXNRD1	WDR97	ENSCAFP00000065153	ENSCAFP00000002224	Thioredoxin reductase 1; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	WD_REPEATS_REGION domain-containing protein.	0.568