STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TLE4TLE family member 4, transcriptional corepressor. (712 aa)    
Predicted Functional Partners:
TCF7
Transcription factor 7.
    
 0.911
RBPJL
Recombination signal binding protein for immunoglobulin kappa J region like.
    
 0.903
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
    
 0.903
TCF7L1
Transcription factor 7 like 1.
    
 0.891
TCF7L2
Transcription factor 7 like 2.
    
 0.891
LEF1
Lymphoid enhancer binding factor 1.
    
 0.891
HDAC1
Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
    
 0.837
HDAC2
Histone deacetylase 2.
    
 0.837
TLE1
TLE family member 1, transcriptional corepressor.
   
 0.821
FRMD3
FERM domain containing 3.
      
 0.794
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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