STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KCNK16-2Ion_trans_2 domain-containing protein. (278 aa)    
Predicted Functional Partners:
KCNJ10
Potassium voltage-gated channel subfamily J member 10.
     
 0.802
KCNK9
Potassium two pore domain channel subfamily K member 9; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
  
 0.799
KCNN3
Potassium calcium-activated channel subfamily N member 3.
     
 0.667
KCNK3
Potassium channel subfamily K member.
   
  
 0.639
KCNMA1
Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...]
   
  
 0.596
CFAP100
Cilia and flagella associated protein 100.
      
 0.582
MARCHF10
Membrane associated ring-CH-type finger 10.
      
 0.550
CCDC189
Coiled-coil domain containing 189.
      
 0.542
KCNE1
Uncharacterized protein.
   
  
 0.535
MECOM
MDS1 and EVI1 complex locus.
      
 0.524
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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