STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TONSLTonsoku like, DNA repair protein. (1354 aa)    
Predicted Functional Partners:
MMS22L
MMS22 like, DNA repair protein.
    
 0.972
SSRP1
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
   
 0.954
MCM2
DNA helicase; Belongs to the MCM family.
   
  0.900
MCM6
DNA helicase; Belongs to the MCM family.
   
 0.882
ASF1A
Anti-silencing function 1A histone chaperone.
   
 
 0.873
SUPT16H
SPT16 homolog, facilitates chromatin remodeling subunit.
    
 0.857
ADCK5
AarF domain containing kinase 5.
      
 0.852
GRINA
Glutamate ionotropic receptor NMDA type subunit associated protein 1.
      
 0.850
ASF1B
Uncharacterized protein.
   
 
 0.833
ASF1B-2
Uncharacterized protein.
   
 
 0.821
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.